Motivated Grad students interested in pursuing PhD degree, starting September 2016
Postdoctoral Fellows with experience in cell and molecular biology - available immediately
Research technician with molecular biology experience - long-term position available immediately - position filled
If you are interested in one of these positions, please contact me by email; make sure to include a cover letter and CV, as well as transcripts for the PhD position.
our research interests
A focus of our studies involves identifying and characterising proteins found within the cilium, an evolutionarily ancient microtubule-based organelle. Using the nematode C. elegans, we study intraflagellar transport, a kinesin- and dynein-dependent transport process necessary for the formation and maintenance of the complex ciliary structure. Cilia are found in a large proportion of unicellular organisms, and in humans, motile and non-motile (primary) cilia play important roles in moving fluids or sensing the extracellular environment. As part of these studies, we probe the molecular basis of some human disorders that arise from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. Genetic disorders involving cilia are characterised by a wide range of ailments, such as obesity, kidney and heart anomalies, blindness, and neurosensory impairment. We are also attempting to understand at the molecular how cilia modulate signaling processes that affect development.
To learn more, visit the research section.
recent research highlights
PLoS Biol. 2016
MKS5 and CEP290-directed assembly pathway of the ciliary transition zone
EMBO J. 2015
MKS5, a central organiser of the transition zone, creates a membrane diffusion barrier at the base of cilia
Curr. Biol. 2013
Rootletin plays a central role in cilium maintenance and function
Am. J. Hum. Genet. 2011
Discovery of novel human disease (ciliopathy) gene, TMEM237
J. Cell Biology 2011
Discovery of role for eight known or suspected ciliopathy proteins in early ciliogenesis and establishment of a ciliary gate
For the full list and abstracts, browse through our publications.
Our lab is home to a multitalented and dynamic group of people with a wide variety of research interests. Information on everyone in the lab and pictures can be found in the team section.
Our research has been generously funded by a variety of Provincial, National and International biomedical and basic science research agencies:
- Canadian Institutes for Health Research (CIHR)
- Heart & Stroke Foundation of Canada (HSFC)
- March of Dimes (MOD)
- Michael Smith Foundation for Health Research (MSFHR)
- National Cancer Institute of Canada (NCIC)
- Natural Sciences and Engineering Research Council (NSERC)
- Canada Foundation for Innovation (CFI)
- BC Knowledge Development Fund (BCKDF)
Contact info, directions can be found here
[ page updated June 3, 2016 ]