Julian Guttman

Professor

Cellular Microbiology

CIHR New Investigator Award

  • Email: jguttman@sfu.ca
  • Tel: 778-782-4459
  • Office: B8276
  • Lab: B7239
  • Lab Tel: 778-782-8618

Education

  • BSc, University of Western Ontario
  • MSc, University of British Columbia
  • PhD, University of British Columbia

Areas of Research

Research Interests

My lab is generally interested in understanding the molecular alterations that occur to epithelial cells during bacterial infections. We have focused primarily on 4 separate aspects related to bacterial infections; 1) alterations to the skeleton within host cells (the cytoskeleton), 2) strategies bacteria use to gain entry to their host cells, 3) the molecular mechanisms of diarrhea generation and 4) the identification of therapeutics for bacterial infections and other diseases.

We utilize a wide variety of bacteria to answer our questions including: Pathogenic E. coli, Salmonella Typhimurium, Listeria monocytogenes, Klebsiella pneumonia, Edwardsiella tarda and the potential bioterrorism agent Francisella tularensis. Technically, we use an array of microbiological and molecular/cell biological tools as well as proteomics to test our hypotheses. We also routinely use light and electron microscopy, 3D imaging, fluorescent protein imaging in live cells as well as RNA interference and CRISPR to uncover sub-cellular alterations caused by these bacteria.

Courses

Future courses may be subject to change.