Presentation Studio at SFU's Big Data Hub
Sarah Cohen, University of North Carolina, Chapel Hill
Advanced imaging approaches to study lipid trafficking within and between cells
Lipids are essential molecules for life. They form the membranes that separate cells from their environments, store energy in a highly concentrated form, and act as important signaling molecules. Within cells, lipids are stored in organelles called lipid droplets. Lipid droplets are comprised of a core of neutral lipids (triglycerides and sterol esters) surrounded by a phospholipid monolayer. Because all other organelles are surrounded by phospholipid bilayers, lipid droplets are not connected to traditional vesicular trafficking pathways. Instead, they can exchange materials with other organelles directly at membrane contact sites. Our lab uses advanced microscopy techniques - including live-cell, multispectral and super resolution microscopy – to study how lipids traffic between lipid droplets and other cellular compartments in response to changing developmental and environmental cues. I will share our findings about the function and dynamics of lipid droplets in three different tissues: muscle, brain, and liver.
For more information: cohenlaboratory.web.unc.edu/