Members of the Centre for Cell biology, Development, and Disease (C2D2) make significant contributions to biomedical research, publishing in prominent Biomedical and Life Sciences journals. Three representative publications from each group are listed here.

Tim Audas

Christopher Beh

Sherryl Bisgrove

  • Gleeson et al. The microtubule associated protein END BINDING 1 represses root responses to mechanical cues. Plant Sci. 2012
  • Bisgrove et al. The microtubule plus-end binding protein EB1 functions in root responses to touch and gravity signals in Arabidopsis. Plant Cell 2008

Jonathan Choy

Julian Christians

Nancy Forde

Sharon Gorski

Nick Harden

  • Vlachos et al. A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary. Development 2015
  • Wang et al. Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction. Biol. Open 2014
  • Wang et al. Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Dev. Biol. 2011

Nancy Hawkins

  • Hingwing K, Lee S, Nykilchuk L, Walston T, Hardin J, Hawkins N. CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway. Dev. Biol. 2009
  • Dolgosheina et al. RNA mango aptamer-fluorophore: a bright, high-affinity complex for RNA labeling and tracking. ACS Chem. Biol. 2014
  • King et al. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. Dev Biol. 2009

Harald Hutter

Charles Krieger

  • Wang et al. Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction. Biol. Open 2014
  • Shan et al. Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Neurosci. Lett. 2012
  • Lewis et al. The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells. Neurol. Res. Int. 2012

Michel Leroux

Carl Lowenberger  

Damon Poburko


Zamir Punja

  • publications

Lynne Quarmby

  • Hilton et al. The kinases LF4 and CNK2 control ciliary length by feedback regulation of assembly and disassembly rates. Curr. Biol. 2013
  • Parker et al. Centrioles are freed from cilia by severing prior to mitosis. Cytoskeleton 2010

Gordon Rintoul

  • Deheshi et al. Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling. J. Neurochem. 2015
  • Deheshi et al. Mitochondrial trafficking in neuropsychiatric diseases. Neurobiol. Dis. 2013
  • Tan et al. Elevated intracellular calcium causes distinct mitochondrial remodelling and calcineurin-dependent fission in astrocytes. Cell Calcium 2011

Peter Ruben

  • Jones et al. Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel. Biophys. J. 2013
  • Jones et al. Proton sensors in the pore domain of the cardiac voltage-gated sodium channel. J. Biol. Chem. 2013
  • Kole et al. Action potential generation requires a high axon initial segment sodium channel density maintained by anchoring to the actin cytoskeleton. Nat. Neurosci. 2008

Michael Silverman


Bingyun Sun

  • Zhang et al. Do housekeeping genes exist? PLoS ONE 2015
  • Sun B. Proteomics and glycoproteomics of pluripotent stem-cell surface proteins. Proteomics 2015
  • Lee et al. Sodium dodecyl sulfate polyacrylamide gel electrophoresis for direct quantitation of protein adsorption. Anal. Biochem. 2014

Glen Tibbits

  • Lin et al. Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2015
  • Dan et al. Phenotype-dependent role of the L-type calcium current in embryonic stem cell derived cardiomyocytes. Am. J. Stem Cells 2014
  • Genge et al. Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner. Physiol. Genomics 2013

Ian Tietjen

Esther Verheyen

  • Swarup et al. Genome-wide in vivo identification of kinases and phosphatases that regulate Wnt signaling. Development 2015
  • Fernandes et al. Integrins regulate apical constriction via microtubule stabilization in the Drosophila eye disc epithelium. Cell Reports 2014
  • Pradhan-Sundd T. and Verheyen EM. The role of Bro1 domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless. Dev. Biol. 2014

Amandio Vieira

  • Fong VH and Vieira A. Pro-oxidative effects of aggregated transthyretin in human Schwannoma cells. Neurotoxicology 2013
  • Pirani et al. Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes. Biochim. Biophys. Acta. 2013
  • Fong VH and Vieira A. Transthyretin aggregates induce production of reactive nitrogen species. Neurodener. Dis. 2013

David Vocadlo