www.sfu.ca

Publications

27. Halperin, S. D.; Kang, B.; Britton, R. 'Lithium Aldol Reactions of alpha-Chloroaldehydes Provide Versatile Building Blocks for Natural Product Synthesis' Synthesis 2011, 12, 1946-1953.

26. Draper, J.; Britton, R. 'A Concise and Stereoselective Synthesis of Hydroxypyrrolidines: Rapid Synthesis of (+)-Preussin'' Org. Lett. 2010, 12 (18), 4034-4037.

25. Kang, B.; Chang, S.; Decker, S.; Britton, R. 'Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans' Org. Lett. 2010, 12 (8), 1716-1719.

24. Kang, B.; Mowat, J.; Pinter, T.; Britton, R. 'Development of a Concise and General Enantioselective Approach to 2,5-Disubstituted-3-hydroxytetrahydrofurans' Org. Lett. 2009, 11 (8), 1717-1720.

23. Mowat, J.; Kang, B.; Fonovic, B.; Dudding, T.; Britton, R. 'Inverse Temperature Dependence in the Diastereoselective Addition of Grignard Reagents to a Tetrahydrofurfural' Org. Lett. 2009, 11 (10), 2057-2060.

22. Cho, I.; Meimetis, L.; Britton, R. 'Bidirectional Metalation of Hydrobenzoin: Direct Access to New Chiral Ligands and Auxiliaries ' Org Lett. 2009, 11 (9), 1903-1906.

21. Mowat, J.; Gries, R.; Gries, G.; Khaskin, G.; Britton, R. '(S)-2-Pentyl (R)-3-Hydroxyhexanoate, a Banana Volatile and Its Olfactory Recognition by the Common Fruit Fly, Drosophila melanogaster' J. Nat. Prod. 2009, 72 (4), 772-776.

20. Britton, R.; Khaskin, G.; Gries, G. 'A chromatography-free synthesis of (2S,12Z)-2-acetoxy-12-heptadecene - The major sex pheromone component of the pistachio twig borer moth (Kermania pistaciella)' Can. J. Chem. 2009, 87(2), 430-432.

19. Kang, B.; Britton, R. 'A General Method for the Synthesis of Nonracemic trans-Epoxides: Concise Syntheses of trans-Epoxide-Containing Insect Sex Pheromones' Org. Lett. 2007, 9(24), 5083-5086.

18. Gosselin, F.; Britton, R.; Mowat, J.; O'Shea, P. D.; Davies, I. W. 'Asymmetric Organozincate Additions to Ethyl 2,2,2-Trifluoropyruvate' Synlett 2007, 14, 2193-2196.

17. Paterson, I.; Ashton, K.; Britton, R.; Cecere, G.; Choraqui, G.; Florence, G.; Knust, H.; Stafford, J. 'Total Synthesis of (-)-Reidispongiolide A, an Actin-Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea' Chemistry - An Asian Journal 2008, 3(2), 367-387.

16. R. Gries, G. Khaskin, H. Daroogheh, C. Mart, S. Karadag, M. Kubilay, R. Britton, G. Gries; ‘(2S,12Z)-2-acetoxy-12-heptadecene: Major sex pheromone component of pistachio twig borer, Kermania pistaciella’ J. Chem. Ecol. 2006, 32(12), 2667-2677.

15. Ian Paterson, Dirk Menche, Robert Britton, Anders E. Hakansson, Maria A. Silvia-Martinez; ‘Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling.’ Tetrahedron Letters, 2005, 46, 3677.

14. Ian Paterson, Robert Britton, Oscar Delgado, Arndt Meyer, Karine G. Poullennec; ‘Total Synthesis and Configurational Assignment of (-)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin.’ Angewandte Chemie, International Edition, 2004, 43, 35, 4629.
Cover picture: Angewandte Chemie International Edition, 2004, 43, 4537. This article was also featured in Chemical and Engineering News, July 12, 2004, 82, 28, 9.

13. Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, Jonathan Stafford ‘Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A.’ Proceedings of the National Academy of Sciences, 2004, 101, 11986.

12. Ian Paterson,Robert Britton,Oscar Delgado, Amy E. Wright; ‘Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.’ Chemical Communications, 2004, 632.

11. Robert Britton, Edward Piers, Brian O.Patrick; ‘Total Synthesis of (±)-13-Methoxy-15-oxozoapatlin, a Rearranged Kaurane Diterpenoid.’ Journal of Organic Chemistry, 2004, 69, 3068.

10. Xiuxian Jiang, Baoguang Zhao, Robert Britton, Lynette Y. Lim, Dan Leong, Jasbinder S. Sanghera, Bin-Bing S. Zhou, Edward Piers, Raymond J. Andersen, Michel Roberge; ‘Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.’ Molecular Cancer Therapeutics, 2004, 3, 1221.

9. Robert Britton, Michel Roberge, Colleen Brown, Rob van Soest, Raymond J. Andersen; ‘New Okadaic Acid Analogues From the Marine Sponge Merriamum oxeato andtheir Effect on Mitosis.’ Journal of Natural Products, 2003, 66, 838.

8. Ian Paterson, Kate Ashton, Robert Britton, Henner Knust; ‘Toward the Synthesis of Reidispongiolide A: Stereocontrolled Synthesis of the C17-C22 and C23-C35 Degradation Fragments.’ Organic Letters, 2003, 5, 1963.

7. Robert Britton, E. Dilip de Silva, Christina M. Bigg, Lianne M. McHardy, Michel Roberge, Raymond J. Andersen; ‘Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabalizing Pharmacophore.’ Journal of the American Chemical Society, 2001, 123, 8632.

6. Robert Britton, Michel Roberge, Hans Berisch, Raymond J. Andersen; ‘Antimitotic Diterpenoids from Erythropodium caribaeorum: isolation artifacts and putative biosynthetic intermediates.’ Tetrahedron Letters, 2001, 42, 2953.

5. Robert Britton, Jaine H. de Oliveira, Raymond J. Andersen, Roberto Berlinck; ‘Granulatimide and 6-Bromogranulatimide: Minor Alkaloids of the Brazilian Ascidian Didemnum Granulatum.’ Journal of Natural Products, 2001, 64, 254.

4. Edward Piers, Robert Britton, Raymond J. Andersen; ‘Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Synthesis of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide and Isogranulatimides A-C.’ Journal of Organic Chemistry, 2000, 65, 530.

3. Roberto Berlinck, Robert Britton, Edward Piers, Raymond J. Andersen, Michel Roberge, Lynette Lim, Rosana Moreira da Rocha; ‘Inibidores do Desenvolvimento Celular: Uma Nova Abordagem para o Tratamento de Tumores Sólidos.’, Estudos Avançados, 1999, 13, 35, 207.

2. Roberto Berlinck, Robert Britton, Edward Piers, Lynette Lim, Michele Roberge, Rosana Moreira da Rocha, Raymond J. Andersen; ‘Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum Granulatum.’ Journal of Organic Chemistry, 1998, 63, 9850.

1. M. Roberge, R. Berlinck, L. Xu, H. Anderson, L. Lim, D. Curman, C. Stringer, S. Friend, P. Davies, I. Vincent, S. Haggarty, M. Kelly, R. Britton, E. Piers, R. Andersen; ‘High Throughput Assay for G2 Checkpoint Inhibitors and Identification of the Structurally Novel Compound Isogranulatimide.’ Cancer Research, 1998, 58, 5701.

Patents

4. R. Gries, G. Khaskin, H. Daroogeh, C. Mart, R. Britton, G. Gries; ‘Composition of Chemicals for Manipulating the Behaviour of the Pistachio Twig Borer, Kermania Pistaciella (Lepidoptera: Oinophilidae)’ PCT Patent Application No. PCT/CA2006/000059. Filed Jan. 6, 2006.

3. O. Delgado, I. Paterson, R. Britton, K. Poullennec, A. Meyer, A. Wright; ‘Methods for the synthesis of dictyostatin and derivatives and analogues thereof, stereochemical characterization, novel dictyostatin compounds and uses thereof and synthetic intermediates’ Publication date: July 28, 2005. Patent No. WO2005068451.
 
2. R. Andersen, M. Roberge, R. Britton, D. De Silva; ‘Antimitotic Eleuthosides’ Publication date: December 30, 2004. Patent No.: US2004266700.
           
1. R. Andersen, M. Roberge, S. Jasbinder, D. Leung, R. Berlinck, E. Piers, R. Britton; ‘Granulatimide Derivatives for use in Cancer Treatment’ Publication date: January 24, 2001. Patent No.: EP1070068 (also published as ‘Granulatimide compounds and uses thereof’ US6291447)

Books / Reviews

2. S. Chang, S. Halperin, J. Moore, R. Britton. "Chiral Auxiliaries in Drug Synthesis" In Stereoselective Synthesis of Drugs and Natural Products. V. Andrushko & N. Andrushko, Eds. Wiley, Accepted

1. Britton, R. ‘Natural Compounds as Drugs, Volumes I and II’ Edited by Petersen, F.; Amstutz, R. 2009