Chemistry Seminar Series

Wed, 21 Nov 2018
Print

Dr. Matthew Pratt

University of Southern California

Chemical Approaches to Understand O-GlcNAc Modifications

Wednesday, November 21, 2018
B9201 @ 3:30 p.m.

Host: Dr. David Vocadlo

Abstract

O-GlcNAc modification is the abundant posttranslational addition of the monosaccharide N-acetyl-glucosamine to serine/threonine residues of intracellular proteins. This modification is absolutely required for mammalian cell survival and is misregulated in a variety of diseases. However, the mechanisms by which O-GlcNAc affects normal and disease biology are still mysterious. My lab aims to investigate O-GlcNAcylation through the development of new chemical probes that enable identification and characterization of modified proteins in living cells and through the semisynthesis of site-specifically modified proteins. Here, I will present some of our work in both of these areas that have led to discoveries about O-GlcNAc in apoptosis in cancer cells and protein aggregation in Parkinson’s disease.