Dr. Warren Chan
University of Toronto
Quantum Dot Smartphone Device for Diagnosing Infected Patients in the Developed and Developing World
Wednesday, January 30, 2019
WMC 3210 @ 3:30 p.m.
Host: Dr. Hogan Yu
Integrating mobile-cellular devices with multiplex molecular diagnostics can potentially provide the most powerful platform for tracking, managing and preventing the transmission of infectious diseases. With over 6.8 billion subscriptions globally, handheld mobile-cellular devices can be programmed to spatially map, temporally track and transmit information on infections over wide geographical space and boundaries. In this presentation, I will discuss recent advances in quantum dot barcode technology with smartphones to engineer a simple and low-cost chip-based wireless multiplex diagnostic device. This device can analyze 20 µL of sample for multiple genetic biomarkers with an analytical sensitivity of 1 – 5 fmol/µL. The addition of an isothermal amplification improve the sensitivity to zmol/ µL to enable the detection of patients infected with HIV and/or hepatitis B from isolated nucleic acid from serum, and identified viral infection in only 1 hour, after blood collection to final read-out. This device advances the capacity for global surveillance of infectious diseases at or near the point-of-care and has the potential to accelerate knowledge exchange-transfer of emerging or exigent disease threats with healthcare and military organizations in real-time.
Dr. Chan is currently the Canadian Research Chair in Nanoengineering in the Institute of Biomaterials and Biomedical Engineering at the University of Toronto. He is also the Head of Biomedical Engineering. Dr. Chan received his B.S. degree from the University of Illinois in 1996, Ph.D. degree from Indiana University in 2001, and post-doctoral training at the University of California (San Diego). He moved to Toronto in 2002 to lead the Integrated Nanotechnology/Biomedical Sciences Laboratory. His research interest is in the development and translation of nanotechnology for diagnosing and treating cancer and infectious diseases. He has received NSERC E. W. R. Memorial Steacie Fellowship, Kabiller Young Investigator Award in Nanomedicine, the BF Goodrich Young Inventors Award, Lord Rank Prize Fund award in Optoelectronics (England), and Dennis Gabor Award (Hungary). He is currently an Associate Editor of ACS Nano. Finally, he is also affiliated with a number of different departments at the University of Toronto: Department of Materials Science and Engineering, the Terrence Donnelly Center for Cellular and Biomolecular Research Chemistry, Chemistry and Chemical Engineering.