MASS Spectrometry Facility

Eric Ye

Supervisor, NMR & MS Systems and Operations

Office: C9039
Lab: C6087
Tel: 778-782-4464 (office)
Email: yegangy@sfu.ca

Hongwen Chen

Mass Spectrometry Specialist

Office: C6085
Lab: C6087
Tel: 778-782-7163 (lab & office)
Email: hongwenc@sfu.ca

The facility provides mass spectral services to researchers at SFU, other universities, hospitals, not-for-profit entities, as well as external commercial clients.

Please contact us to discuss your MS needs.  Pricing is available on request.

Sample Submission

The mass spectrometry facility's sample drop-off box is located just outside the entrance to the NMR and MS facility on the 6000 level of the Chemistry Department (Shrum Science Centre), near Science Stores.  The top and bottom compartments are for sample-drop off and pick-up, respectively.

Samples must be submitted with a completed sample submission form.

For samples that are not stable at room temperature, please contact Hongwen Chen to arrange special receiving.

Useful documents: a new sample submission form, a brief guide to Mass Spec Services and a price list for MS analyses.  

Bruker maXis Impact

Ultra-High Resolution Quadrupole    Time-of-Flight    LC/MS/MS System

  • Sub-ppm mass accuracy and 40,000 Full-Sensitivity Resolution for complex, high-background matrices
  • Market-leading isotopic fidelity for definitive molecular formulae determination with Smart Formula and Smart Formula 3D
  • Extreme sensitivity across the entire mass range from very small molecules to intact proteins
  • Specialty software packages: BioTools, ProfileAnalysis, MetaboliteTools, TargetAnalysis
  • Electrospray Ionization Source (ESI Positive and Negative)
  • Agilent 1200 SL LC System

Bruker micrOTOF

Time-of-Flight    LC/MS System

  • Moderate mass accuracy and resolution
  • Routine molecular weight verification
  • Electrospray Ionization Source (ESI Positive and Negative)
  • Agilent 1200 SL LC System

Agilent 6210

Time-of-Flight    LC/MS System

  • Identification of small molecules based on accurate mass and isotopic abundance and chemical composition using Find by Formula in MassHunter software
  • Application for wide mass range from very small molecules to intact proteins
  • Specialty software packages: BioConfirm
  • Electrospray Ionization Source (ESI Positive and Negative)
  • Multimode Ionization Source (ESI and/or APCI Positive and Negative)
  • Agilent 1200 SL LC System
  • Accessible in Prof. R. Young’s lab

AB Sciex 4000 Q TRAP

LC/MS/MS System

  • High-sensitivity full-scan MS, MS/MS, and MS3 with high-selectivity from true triple quadrupole precursor ion (PI) and neutral loss (NL) scans
  • Multiple reaction monitoring (MRM) for quantitation using high-sensitivity triple quadrupole
  • Electrospray Ionization Source (ESI Positive and Negative)
  • Atmospheric Pressure Chemical Ionization Source (APCI Positive and Negative)
  • Dionex Ultimate 3000 LC System
  • Accessible in Prof. D. Vocadlo’s lab

Thermo Q-Exactive HF Orbitrap

nanoLC-MS/MS system for proteomics analysis

  • Q-Exactive HF is a Hybrid Quadrupole-Orbitrap Mass Spectrometer, equipped with an Ultrahigh-Field Orbitrap, which provides accurate and highly sensitive detection of peptides in complex biological samples
  • Easy nLC 1000 UHPLC delivers nanoliter per minute accurate and highly reproducible flow rate
  • Easy-Spray nanoESI source with reliable and reproducible ionization for the state-of-the-art performance of both expert and nonexpert users
  • High throughput (> 1000 proteins/h) and high sensitivity (attomole)
  • Discovery based shotgun proteomics and targeted PRM analysis
  • Accessible in Prof. B. Sun’s lab