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Travel Report: Yifan Jian, United States

May 09, 2014
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Yifan Jian, a Doctoral student in Engineering Science, received a Graduate International Research Travel Award to further his research in the United States. His report:

Thanks to the SFU graduate international research travel award, I was able to travel to UC Davis to work with our collaborator Dr. Robert Zawadzki on developing novel Adaptive Optics Optical Coherence Tomography imaging system.

Optical coherence tomography (OCT) is a non-invasive micron-resolution volumetric imaging modality. OCT is indispensable for diagnosing eye diseases, it provides volumetric visualizations of the retinal cell layers, and the decisions for pharmaceutical, laser, or surgical treatments in the eye are made based on these OCT volumetric images.

Dr. Robert Zawadzki is an expert and inventor of Adaptive Optics OCT, where he borrowed adaptive optics from astronomy and used it in human ophthalmic OCT imaging to increase the optical resolution. It was a great opportunity for me to work with him on further developing this technology. Dr. Zawadzki and Dr. Pugh were awarded a research funding to build a retinal imaging center (UC Davis EyePod lab) to study the biology of the retina. During my stay at Davis, I built two complex retinal OCT imaging systems in EyePod lab, a large field of view system and a lens-based adaptive optics OCT system from scratch, and they are now being used on daily basis by other scientist.

Besides UC Davis EyePod lab, I also worked at UC Davis Vision Science and Advanced Retinal Imaging Laboratory (VSRI) in Department of Ophthalmology & Vision Science at Sacramento where I deployed my GPU accelerated OCT acquisition and processing software, and it has been used in both research and clinical purpose since.

As the results of this trip, I attended ARVO annual conference at Seattle and gave a talk and co-authored on 2 presentations for the work I have done in Davis [1]–[3]. Furthermore, Dr. Zawadzki, Dr. Sarunic my SFU PhD supervisor and I published this work at a highly regarded journal in our field [4]. Not only finished we have proposed in the beginning, with our complementing skills set we have incubated the idea of wavefront sensorless adaptive optics OCT which combines both Dr. Zawadzki’s and mine expertise that later led to a high impact journal publication [5]. This paper was the top downloaded paper of Biomedical Optics Express in February and March issues. We are currently applying a patent application that is based on this technology and planning the further development and commercialization.

Our collaboration did not stop at the end of my visit, Dr. Sarunic and I came back to Davis after a conference at San Francisco this year and worked on one more collaborative project with Dr. Zawadzki and Dr. Stefano Bonora who was visiting from Italy. This work will be submitted to an even higher impact journal.

Besides being my mentor and supervisor at work, Robert and I are also good friends, we shared lots common interests. Robert took to watch my first NBA game in my life in Sacramento. I had an amazing time at Davis both professionally and personally. Again, I am very grateful to SFU graduate international research travel award for granting me this wonderful opportunity.

1. R. J. Zawadzki. Y. Jian, J. S. Werner, K. Wong, E. N. Pugh, M. V. Sarunic, “Imaging the mouse retina in vivo using Adaptive Optics - Fourier Domain Optical Coherence Tomography,” Assoc.
Res. Vis. Ophthalmol, 2013.
2. S. H. Lee, Y. Jian, R J. Zawadzki, J. S. Werner, “Improved cellular resolution retinal imaging with aberration free and pupil wander free reflective Adaptive Optics - Optical Coherence
Tomography Imaging System,” Assoc. Res. Vis. Ophthalmol., 2013.
3. R. J. Zawadzki, Y. Jian, M. V. Sarunic, J. S. Werner, “Application of phase variance optical coherence tomography for in-vivo imaging of retinal micro vasculature in mice,” Assoc. Res. Vis.
Ophthalmol., 2013.
4. Y. Jian, R. J. Zawadzki, and M. V Sarunic, “Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.,” J. Biomed. Opt., vol. 18, no. 5, p. 56007, May 2013.
5. Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,”
Biomed. Opt. Express, vol. 5, no. 2, p. 547, Jan. 2014.

Tags: Student Voices; Engineering Science

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