Biomarkers derived from brain magnetic resonance (MR) imaging have promise in being able to assist in the clinical diagnosis of brain pathologies. These have been used in many studies in which the goal has been to distinguish between pathologies such as Alzheimer’s disease and healthy aging. However, other dementias, in particular, frontotemporal dementia, also present overlapping pathological brain morphometry patterns. In this stream of research, we investigate novel methods for the differential diagnosis of various neurodegenrative diseases in a multi-class setting, and explore novel methods and techniques to improve the differential diagnostic accuracy.
Pradeep Reddy, Howard Rosen, Bruce Miller, Michael Weiner, Lei Wang, Mirza Faisal Beg, Three class differential diagnosis among AD, FTD and controls, Frontiers in Neurol- ogy, 5(71), 2014.