Imaging genetics

Both genetic variants and brain region abnormalities are recognized to play a role in cognitive decline. In this project, we explore the relationship between genome-wide variation and region-specific rates of decline in brain structure, as measured by magnetic resonance imaging.

Above: Manhattan plot of association between genetic markers and cognitive impairment, adjusted for confounders.

Below: Heatmap of the rates of change in MRI features with coloured disease labels, adjusted for confounders.