FHS Seminar Series - Control of pathological immune responses by inflammatory and microbial signals

by Dr. Jonathan Choy, Associate Professor, Department of Molecular Biology and Biochemistry, SFU

January 24, 2019

Event Type

Seminar Series

Date

January 24, 2019 at 12:00 pm to 1:15 pm

Location

Blusson Hall, Room 9920

Abstract 

The immune system protects our bodies against infections but its inappropriate activation underlies the development of many pathological health conditions.  Organ transplant rejection and autoimmune diseases are related conditions in which the immune system targets healthy organs/tissues in the body and, in this way, can cause life-threatening organ failure.  Our research has examined how inflammatory signals and early life microbial exposure affects immune responses that cause these conditions.  I will discuss recent findings showing that the inflammatory cytokine, IL-6, contributes to T cell activation and antibody production that causes transplant rejection and vascular autoimmunity as well as how disruption of commensal bacteria in the gut affects immune responses that cause transplant rejection.

Biography

Jonathan Choy is Associate Professor in the Department of Molecular Biology and Biochemistry at SFU.  His research focuses on how immune responses are activated to cause the rejection of transplanted organs and the development of autoimmune diseases.

  • This Seminar Series is open to the SFU and the Broader Research Community.  
  • This seminar will be webcasted and recorded.
  • A light lunch will be available at this seminar.  
  • The FHS Research Seminar Series is an Accredited Small Group Learning by the Royal College of Physicians and Surgeons.