The HTCB can assist researchers with screening projects using a variety of assistance models. For occasional users the center can provide end to end support, starting with assay design and development, transitioning to full HTS campaigns, and concluding with data analysis and report generation.
More advanced users with HTS-ready systems can be assisted to translate these screens to our platform, select appropriate compound libraries, and process output data to prioritize screening hits.
Finally, users with extensive experience in HTS environments can obtain training to run the platform independently, reducing screening costs and permitting additional assay protocol optimization.
The HTCB offers a suite of standard high-throughput screens to both internal and external users at very competitive rates. These include antimicrobial assays against a range of clinically relevant bacterial pathogens, pure protein assays, and high-content cytological profiling assays against a set of human cancer cell lines.
If required these assays can be run as fee-for-service experiments using owner-generated compound code numbers so that your proprietary data remains secure and private. Data is stored in our online data management system, permitting easy access from anywhere in the world, but limiting access to your selected research team. Users can access only the data in their own project, meaning that you and only you have permission to view, analyze and download your screening results.
We are offering a pilot program to new on-campus users to defray costs for the first project performed in the HTCB. The aim of this program is to lower the barrier to entry for new users, and to give members of the university the opportunity to explore the value of the HTCB to their research programs.
Tenured or tenure track faculty with full-time appointments at SFU are eligible to apply.
Each faculty member may receive up to one pilot program award. Multiple awards to a single faculty member are not permitted.
Pilot program awards must be applied to a single pilot project and cannot be distributed across multiple projects.
At the completion of the pilot project any unused portion of the award reverts back to the HTCB.
Pilot program award requests will be reviewed and approved by the HTCB management committee.
The pilot program provides support through reduction in recharge fees for instrument time and HTCB research scientist time only.
Researchers are responsible for associated consumable costs including but not limited to plates, tips, compounds plate recovery fee, reagents, filters, cultureware, PPE etc.
The total value of the award is up to $4000. This is split into two components: up to $1500 for screen development and up to $2500 for an initial pilot screen. Screen development is defined as work required to optimize assays for the high-throughput environment. This will typically involve testing of control compounds in small batches and assay protocol optimization. Pilot screens are defined as activities requiring use of the full screening platform for one or more 24 hour period. It is expected that pilot screens will provide screening results for 1,000 - 10,000 compounds.
Recipients of pilot program awards are expected to make use of screening results through the publication of research findings and application for new research grants.