1. Initiate a Project
To start screening, please fill out the screen proposal form and email to email@example.com.
The screen proposal form will summarizes your aims, as well as your protocol. See our Additional Resources section for some useful information on screening development.
After your request has been submitted, you will be contacted to set up an initial meeting.
2. Complete User Agreements
After your project has been accepted, complete the following forms and and email to firstname.lastname@example.org.
User agreement form (select the form most applicable)
3. Obtain Biosafety Review/Approval
All users must obtain biosafety review (external user) or biosafety approval (internal users).
More information can be found on the SFU Environmental Health and Safety website.
4. Register at QReserve
Register at the QReserve website, which handles all instrument reservations.
All users must receive training sessions on the pieces of equipment that will be using. You will be prompted to arrange a training session with the HTCB Research Scientist upon your first time booking each piece of equipment.
6. Screening Pipeline
For more information about the screening pipeline, please consult our pipeline flowchart.
Information for screening development
To assist in the development of screens and to aid in identifying promising chemical matter we have started a small collection of literature references that users and potential users should find useful as a point of reference. The topics covered include:
Note that hits obtained from high throughput screens are a starting point and require rigorous follow up assessment including evaluation of resynthesized compound, validation in a distinct secondary assay, and assessing the quality of the hit to rule out, for example, promiscuous electrophilic compounds or redox active compounds known as PAINS. Also reasonable common are hits that inhibit enzyme activity through compounds aggregating to form microscopic colloids that inhibit or inactivate compounds.