Publications
Wang, S., Yang, J., Tsai, A., Kuca, T., Sanny, J., Lee, J., Dong, K., Harden, N. and Krieger, C. (2011). Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Dev. Biol. in press. Abstract
Vlachos, S., and Harden, N. (2011). Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics 187: 501-512. Abstract
Bahri, S., Wang, S., Conder, R., Choy, J., Vlachos, S., Dong, K., Merino, C., Sigrist, S., Molnar, C., Yang, X., Manser, E., and Harden, N. (2010) The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. Development 137:2023-2032. Abstract
Fricke, R., Gohl, C., Dharmalingam, E., Grevelhörster, A., Zahedi, B., Harden, N., Kessels, M., Qualmann, B., and Bogdan, S. (2009) Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE. Curr. Biol. 19:1429-1473. Abstract
Zahedi, B., Shen, W., Xu, X., Chen, X., Mahey, M., and Harden, N. (2008) Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Dev. Dyn. 237:2936-2946. Abstract
Conder, R., Yu, H., Zahedi, B., and Harden, N. (2007) The serine/threonine kinase dPak is required for polarized assembly of F-actin bundles and apical-basal polarity in the Drosophila follicular epithelium. Dev. Biol. 305:470-482. Abstract
Sanny, J., Chui, V., Langmann, C., Pereira, C., Zahedi, B., and Harden, N. (2006) Drosophila RhoGAP68F is a putative GTPase activating protein for RhoA participating in gastrulation. Dev. Genes Evol. 216:543-550. Abstract
Tsuda, M., Langmann, C., Harden, N., and Aigaki, T. (2005). The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep 6:1082-1087. Abstract
Conder, R., Yu, H., Ricos, M., Hing, H., Chia, W., Lim, L., and Harden, N. (2004) dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev. Biol. 276: 378-390. Abstract
Wei, H.-C., Sanny, J., Shu, H., Baillie, D. L. , Brill, J. A., Price, J. V. and Harden, N. (2003). The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Curr. Biol. 13: 1882-1887. Abstract
Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J. L. and Giangrande, A. (2003). CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the Fragile X protein. Neuron 38: 887-898. Abstract
Harden, N. (2002). Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70:181-203. Abstract
Sem, K.P., Zahedi, B., Tan, I., Deak, M., Lim, L., and Harden, N. (2002). ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Mol. Cell. Biol. 22:3685-97. Abstract
Harden, N., Ricos, M., Yee, K., Sanny, J., Langmann, C., Yu, H., Chia, W., and Lim, L. (2002). Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J Cell Sci. 115:2119-29. Abstract
Technical Publication. Harden, N. and Lim, L. Bio-Rad Application Note MRC-A27. Characterization of developmental regulation of the cytoskeleton using confocal microscopy.
Hing, H., Xiao, J., Harden, N., Lim, L., and S. L. Zipursky. (1999). Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97: 853-863. Abstract
Ricos, M., Harden, N., Sem, K. P., Lim, L. and Chia, W. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112: 1225-1235. Abstract
Harden, N., Ricos, M., Ong, Y. M., Chia, W. and Lim, L. (1999). Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-284. Abstract
Crawford, J. M., Harden, N., Leung, T., Lim, L., and Kiehart, D. P. (1998). Cellularization in Drosophila melanogaster is disrupted by the inhibition of Rho activity and the activation of Cdc42 function. Dev. Biol. 204: 151-164. Abstract
Harden, N., Lee, J., Loh, H.-Y., Ong, Y.-M., Tan, I., Leung, T., Manser, E., and Lim, L. (1996). A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896-1908. Abstract
Harden, N., Loh, H. Y., Chia, W., and Lim, L. (1995). A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121: 903-914. Abstract
