2014

Fernandes, V.M., McCormack, K., Lewellyn, L. and E.M. Verheyen (2014) Integrins regulate apical constriction via microtubule stabilization in the Drosophila eye disc epithelium. Cell Reports, in press.


Fernandes, V.M., Braid, L.R. and E.M. Verheyen (2014) Nemo is a conserved core proneural target involved in Notch-mediated lateral inhibition during neurogenesis. Developmental Biology, 392: 334-343.


Pradhan-Sundd, T. and E.M. Verheyen (2014) The role of Bro1 domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless. Developmental Biology, 392: 93-107. Also featured on the cover!


Blaquiere, J., Lee, W. and E.M. Verheyen (2014) Homeodomain-interacting protein kinase promotes normal and ectopic eye development through repression of twin of eyeless and eyeless. Developmental Biology, 390:14–25.  Also featured on the cover!


2013

This article in Science Signaling features our work on Hipk and the Hippo pathway (Chen and Verheyen, 2012).


2012

Chen, J. and E.M. Verheyen (2012) Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth. Current Biology, e-pub July 26, 2012. PDF


Verheyen, E.M., Swarup, S. and W. Lee (2012) Hipk proteins dually regulate Wnt/Wingless signal transduction. Fly 6: 1-6, e-pub June 2012. PDF


Swarup, S. and E.M. Verheyen (2012) Wnt/Wingless signaling in Drosophila. CSH Perspectives, e-pub April 25, 2012. PDF


Morillo, S.A., Braid, L.R., Verheyen #, E.M. and I. Rebay # (2012) Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Developmental Biology, 365(1):267-76. # joint corresponding authors.


2011

Swarup, S. and E.M. Verheyen (2011) Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc. Natl. Acad. Sci. USA, 108 (24): 9887-9892, e-pub May 31, 2011, PDF.


Mirkovic, I., Gault, W.J.*, Rahnama, M.*, Jenny, A.*, Gaengel, K., Bessette, D., Gottardi, C.J., Verheyen, E.M.# and M. Mlodzik# (2011) The Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin/β-catenin. Nature Structural & Molecular Biology 18: 665–672, e-pub May 8, 2011, PDF. # joint corresponding authors, * joint second authors.


2010

Verheyen, E.M. and H. Clevers (2010) Wnts as self-renewal factors: mammary stem cells and beyond. Cell Stem Cell 6: 494-495, PDF. (A preview of a Cell Stem Cell paper written by my former PhD student Arial Zeng and Roel Nusse).


Braid, L.R.*, Lee, W.*, Uetrecht, A.C., Swarup, S., Papaianni, G., Heiler, A. and E.M. Verheyen (2010) Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis.  Developmental Biology 343(1-2):178-89.  *joint first authors. PDF


Verheyen, E.M. and C.J. Gottardi (2010) Regulation of Wnt/beta-catenin signaling by protein kinases.  Developmental Dynamics 239(1):34-44, e-pub Jul 21, 2009,  PDF


2009

Merino, C., Penney, J., González, M., Tsurudome, K., Moujahidine, M., O’Connor, M.B., Verheyen, E.M. and P. Haghighi (2009) Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila NMJ. Journal of Cell Biology 185(4): 713-25, PDF.


Lee, W., Swarup, S., Chen, J., Ishitani, T. and E.M. Verheyen (2009b) Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression. Development 136: 241-251, e-pub Dec. 16, 2008. PDF


Lee, W., Andrews, B.C., Faust, M., Walldorf, U. and E.M. Verheyen (2009a) Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho. Developmental Biology 325: 263-272, e-pub Nov. 5, 2008. PDF.


2008

Zeng, Y.A.*, Rahnama, M.*, Wang, S., Lee, W. and E.M. Verheyen (2008) Inhibition of Wg signaling through activated BMP involves competition between Mad and Armadillo/β-catenin for dTcf binding. PLoS ONE 3(12): e3893. *joint first authors. PDF


Braid, L.R. and Verheyen, E.M. (2008) Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network.  Genetics 180: 283-299. PDF


2007

Verheyen, E.M. (2007) Opposing effects of Wnt and MAPK on BMP/Smad signal duration.  Developmental Cell 13: 755-756. PDF


Zeng, Y.A.*, Rahnama, M.*, Wang, S., Sosu-Sedzorme, W. and E.M. Verheyen (2007) Drosophila Nemo/Nlk antagonizes Bone Morphogenetic Protein signalling by phosphorylation of Mad and inhibition of its nuclear accumulation. Development 134: 2061-2071,  *joint first authors.  PDF

 

2004

Zeng, Y.A. and Verheyen, E.M. (2004) Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development. Development 131: 2911-2920. PDF


2002

Mirkovic, I.,Charish, K., Gorski, S.M., McKnight, K., and Verheyen, E.M. (2002) Drosophila nemo is an essential gene involved in the regulation of programmed cell death. Mechanisms of Development 119: 9-20. PDF


MacLean, S.J., Andrews, B.C., and Verheyen, E.M. (2002) Characterization of Dir: a putative potassium inward rectifying channel in Drosophila. Mechanisms of Development 116: 193-197. PDF


2001

Verheyen, E.M., Mirkovic, I., MacLean, S.J., Langmann, C., Andrews, B.C., and MacKinnon, C. (2001) The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development. Mechanisms of Development 101: 119-132. PDF