Mark Brockman

Education

  • B.A., Beloit College 
  • Ph.D., Harvard University

Research Interests

The research in our laboratory uses molecular and cell biology methods to investigate key questions at the interface of virology, pathogenesis, and the human cellular immune response to human immunodeficiency virus (HIV) infection. Ongoing studies aim to understand the impact of viral immune escape mutations on HIV protein function and cytotoxic T lymphocyte (CTL) recognition, to assess the role of HIV accessory proteins in establishment and maintenance of viral latency, and to employ new assays to identify patient-derived T cell receptors (TCR) that display enhanced ability to recognize HIV-infected cells.

For more information, visit our research lab website.

Selected Publications:

  • Ogunshola, Anmole, et al(2018) Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV Gag escape variants. Nature Communications (Accepted)
  • Alsahafi et al. (2017) Impaired downregulation of NKG2D ligands by Nef protein from elite controllers sensitize HIV-1-infected cells to ADCC. Journal of Virology 91(16):e00109-17. doi: 10.1128/JVI.00109-17
  • Mwimanzi et al. (2016) Novel acylguanidine-based inhibitor of HIV-1. Journal of Virology 90(20):9495-508. doi: 10.1128/JVI.01107-16
  • Cotton, Kuang, Le et al. (2014) Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic. PLoS Genetics 10(4):e1004295. doi: 10.1371/journal.pgen.1004295
  • Kuang et al. (2014) Impaired Nef function is associated with early control of HIV-1 viremia. Journal of Virology 88(17):10200-13. doi: 10.1128/JVI.01334-14

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Courses

This instructor is currently not teaching any courses.