- B.Sc., University of British Columbia
- M.Sc., Simon Fraser University
- Ph.D., Simon Fraser University
We are interested in understanding the molecular mechanisms underpinning bacterial virulence. How do bacteria assemble and secrete virulence factors that allow them to colonise a host and cause disease? We apply x-ray crystallography, electron microscopy and genetic analysis to obtain atomic level structure/function information on molecules and molecular machines that impart virulence on bacterial pathogens. This information will guide the development of antimicrobial therapies aimed to disarm rather than kill bacteria in order to minimize antibiotic resistance.
- Wang, F, Coureuil, M, Osinski, T, Orlova, A, Altindal, T, Gesbert, G, Nassif, X, Egelman, EH and Craig, L (2017). Cryo-electron microscopy reconstruction of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV pili at sub-nanometer resolution. Structure, 25, 1423-1435, PMID 28877506. http://www.sciencedirect.com/science/article/pii/S0969212617302502?via%3Dihub
- Ng, D, Harn, T, Altindal, T, Kolappan, S, Marles, JM, Lala, R, Spielman, I, Gao, Y, Hauke, CA Kovacikova, G., Verjee, Z, Taylor, RK, Biais, N and Craig, L (2016). The Vibrio cholerae minor pilin TcpB initiates assembly and retraction of the toxin-coregulated pilus. PLoS Pathogens, e1006109, PMID 27992883. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006109
- Kolappan, S, Coureuil, M Yu, X, Nassif, X, Egelman, EH and Craig, L (2016). Structure of the Neisseria meningitidis Type IV pilus. Nat Commun. 7:13015, PMID 27698424. http://www.nature.com/articles/ncomms13015
Future courses may be subject to change.