- B.Sc. in Biochemistry, McGill University
- Ph.D. in Biochemistry, UBC
The focus of our studies is to identify and characterise proteins found within the cilium, an evolutionarily ancient microtubule-based organelle found on virtually all human cells. Using the nematode C. elegans, we study intraflagellar transport, a kinesin- and dynein-dependent transport process necessary to forma and maintain the complex ciliary structure. We also aim to understand the makeup and function of the transition zone, a ‘gate’ that controls ciliary composition and thus function. Importantly, our biomedical research probes the molecular basis of several human disorders arising from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. Such ‘ciliopathies’ are characterised by a wide range of ailments, such as obesity, kidney and heart anomalies, blindness, skeletal malformations, and neurosensory impairment.
For more information, visit our research lab website.
- Jensen et al. Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary ciliary abundance. EMBO J 2015
- Sung and Leroux. The roles of evolutionarily conserved functional modules in cilia-related trafficking. Nat Cell Biol. 2013
- Mohan et al. Striated rootlet and nonfilamentous forms of rootletin maintain ciliary function. Curr Biol. 2013
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