Peter Unrau

Professor

Education

  • B.Sc., McMaster University
  • Ph.D., M.I.T. 

Biography

Peter Unrau’s education includes a B.Sc. in Physics and Mathematics from McMaster University (1992) and a Ph.D. in Theoretical Physics from MIT (1996). Following his graduation from MIT, Peter became interested in the emerging field of RNA catalysis and decided to join David Bartel’s laboratory as a postdoctoral fellow at the Whitehead Institute for Biomedical Research. His work there, which includes isolating the first RNA nucleotide synthase ribozyme, has been cited numerous times in the literature as a highly significant contribution to the RNA catalysis field.

In 2001, Peter joined the faculty at Simon Fraser University where, with the help of his bright and energetic lab members, he runs an active research program in the area of RNA catalysis. He is currently Professor in the Department of Molecular Biology and Biochemistry at Simon Fraser University, a Michael Smith Foundation Senior Scholar, and a member of the Faculty of 1000.

Selected Publications: 

  • Robert J. Trachman, III, Amir Abdolahzadeh, Alessio Andreoni, Razvan Cojocaru, Jay R. Knutson, Michael Ryckelynck, Peter J. Unrau, and Adrian R. Ferré-D’Amaré. Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness, Biochemistry, 2018.
  • Robert J Trachman III, Natalia ADemeshkina, Matthew W L Lau, Shanker Shyam SPanchapakesan,  Sunny C Y Jeng, Peter J Unrau & Adrian RFerré-D’Amaré*. Structural basis for high-affinity fluorophore binding and activation by RNA Mango, Nature Chemical Biology, 2017.
  • Elena V. Dolgosheina and Peter J. Unrau. Fluorophore-binding RNA aptamers and their applications, WIREs RNA, 2016.

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