Selected Publications: Choy Lab
- Granville DJ, Cassidy BA, Ruehlmann DO, Choy JC, Brenner C, Kroemer G, van Breemen C, Margaron P, Hunt DW, McManus BM. (2001) Mitochondrial release of apoptosis inducing factor and cytochrome c during smooth muscle cell apoptosis. Am J Pathol. 159: 305-311
- Choy JC, Granville DJ, Hunt DWC, McManus BM. (2001) Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol. 33: 1673-90
- Granville DJ, Ruehlmann DO, Choy JC, Cassidy BA, Thompson CB, van Breemen C, McManus BM. (2001) Bcl-2 increases emptying of endoplasmic reticulum Ca2+ stores during photodynamic therapy-induced apoptosis. Cell Calcium. 30(5):343-50
- Singaraja RR, Fievet C, Castro G, James ER, Hennuyer N, Clee SM, Bissada N, Choy JC, Fruchart JC, McManus BM, Staels B, Hayden MR. (2002) Increased ABCA1 activity protects against atherosclerosis. J Clin Invest. 110(1):35-42
- Petersen HH, Choy J, Stauffer B, Moien-Afshari F, Aalkjaer C, Leinwand L, McManus BM, Laher I. (2002) Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 283(6):H2244-2249
- Yanagawa B, Spiller OB, Choy J, Luo H, Cheung P, Zhang M, Goodfellow IG, Evans DJ, Suarez AC, Yang D, McManus BM. (2002) Coxsackievirus B3-associated myocardial pathology and viral load is reduced by recombinant soluble human decay-accelerating factor in mice. Lab Invest. 83(1): 75-85
- Choy JC, McDonald PC, Suarez A, Hung VH, Wilson JE, McManus BM, Granville DJ. (2003) Granzyme B in atherosclerosis and transplant vascular disease: Association with cell death and atherosclerotic disease severity. Mod Pathol. 16(5):460-470
- Moien-Afshari F, Kenyon E, Choy JC, Battistini B, McManus BM, Laher I. (2003) Long-term effects of ovariectomy and estrogen replacement on endothelial function. Maturitas. 45(3): 213-223
- Choy JC, Podor TJ, Yanagawa B, Lai J, Granville DJ, Rezai N, Walker DC, McManus BM. (2003) The regulation and consequences of immune-mediated cell death in atheromatous disease. Cardiovasc Toxicol. 3(3):269-282
- Choy JC, Lui AH, Moien-Afshari F, Wei K, Yanagawa B., McManus BM, Laher I. (2004) Coxsackievirus B3 infection compromises agonist-induced vasodilation of coronary resistance arteries. J Cardiovasc Pharmacol. 43(1):39-47
- Moien-Afshari F, Choy JC, McManus BM, Laher I. (2004) Cyclosporine A treatment preserves coronary artery function in rat cardiac allografts. J Heart Lung Transplant. 23(2):193-203
- Yanagawa B, Spiller OB, Proctor DG, Choy J, Luo H, Zhang HM, Suarez A, Yang DC, McManus BM. (2004) Soluble recombinant coxsackie adenovirus receptor abrogates coxsackievirus B3-mediated pancreatitis as well as myocarditis in mice. J Infect Dis. 189(8):1431-1439
- Choy JC, Kerjner A, Wong BW, McManus BM, Granville DJ. (2004) Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts. Am J Pathol. 165(1):127-133
- Choy JC, Hung VH, Hunter AH, Cheung PK, Motyka B, Goping IS, Sawchuk T, Bleackley RC, McManus BM, Granville DJ. (2004) Granzyme B induces smooth muscle cell death in the absence of perforin: Involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol. 24(12):2445-2450
- Choy JC, Cruz RP, Kerjner A, Giesbrecht J, Sawchuk T, Fraser SA, Hudig D, Bleackley RC, Jirik FJ, McManus BM, Granville DJ. (2005) Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. Am J Transplant. 5(3):494-499
- Hunter AH, Choy JC, Granville DJ. (2005) Detection of apoptosis in cardiovascular diseases. Methods Mol Med. 112:277-290
- Choy JC, Wang Y, Tellides G, Pober JS. (2007) Induction of inducible NO synthase in bystander human T cells increases allogeneic responses in the vasculature. Proc Natl Acad Sci USA., 104(4):1313-1318
- Bai Y, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett F, Bothwell AL, Pober JS, Tellides G. (2008) Interferon-g induces XIAP-associated factor-1 and Noxa expression and potentiates apoptosis of human vascular smooth muscle cells by STAT3 activation. J Biol Chem., 283(11):6832-6842
- Choy JC, Yi T, Rao DR, Tellides G, Fox-Talbot K, Baldwin WM III, Pober JS. (2008) CXCL12 induction of iNOS expression in human CD8 T cells. J Heart Lung Transplant., 27(12):1333-1339
- Choy JC and Pober JS. (2009) Paracrine generation of NO by bystander human CD8 T cells augments allogeneic responses by inhibiting cytokine deprivation-induced cell death. Am J Transplant., 9(10):2281-2291
- Choy JC. (2010) Granzymes in solid organ transplant rejection. Cell Death Diff., 17(4):567-576
- Ahmad U, Qin L, Lo L, Yakimov AO, Khan S, Choy JC, Pober JS, Tellides G. (2010) Interferon-g primes intact human coronary arteries and cultured coronary vascular smooth muscle cells to double-stranded RNA and self-RNA-induced proinflammatory effects of RNA by upregulating TLR3 and MDA5. J Immunol., 185(2):1283-1294
- Escalante NK, von Rossum A, Lee M, Choy JC. (2011) CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells. Arterioscler Thromb Vasc Biol., 31(5):1177-1184
- von Rossum A, Krall R, Escalante NK, Choy JC. (2011) Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP expression. J Biol Chem., 286(24):21137-21144
- Liu A, Lee M, McManus BM, Choy JC. (2012) Induction of eNOS expression by IL-17 in human endothelial cells: Implications for vascular remodeling in transplant vasculopathy. J Immunol., 188(3):1544-1550
- Lee M and Choy JC. (2013) Positive feedback regulation of human inducible nitric oxide synthase expression by Ras S-nitrosylation. J Biol Chem., 288(22):15677-15686
- von Rossum A, Enns W, Shi YP, MacEwan GE, Malekesmaeli M, Brinkman R, Choy JC. (2014) Bim regulates alloimmune-mediated vascular injury through effects on T cell activation and death., Arterioscler Thromb Vasc Biol, 34(6):1290-1297
- von Rossum A, Laher I, Choy JC. (2015) Immune-mediated vascular injury and dysfunction in transplant arteriosclerosis. Front Immunol, 5:684
- Enns W, von Rossum A, Choy J. (2015) Mouse model of alloimmune-induced vascular rejection and transplant arteriosclerosis. J Vis Exp, (99):e52800
- von Rossum A, Rey K, Enns W, Manku S, Cheema R, MacEwan GE, Choy JC. (2016) Graft-derived IL-6 amplifies proliferation and survival of effector T cells that drive alloimmune-mediated vascular rejection. Transplantation, 100(11):2332-2341
- Nesbitt JR, Steves, EY, Schonhofer CR, Cait A, Manku S, Yeung JF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM. (2018) The Aspergillus fumigatus Kdnase (sialidase) contributes to cell wall integrity and virulence. Front Microbiol, 8:2706
- Manku S, Wong W, Luo Z, Alabdurubalnabi Z, Seidman MA, Rey K, Enns W, Avina-Zubieta JA, Shojania K, Choy JC. (2018) IL-6 expression is correlated with increased T cell proliferation and survival in the arterial wall in giant cell arteritis. Cardiovasc Pathol, 33:55-61
- Rey K, Manku S, Enns W, Van Rossum T, Bushell K, Morin RD, Brinkman FSL, Choy JC. (2018) Disruption of the gut microbiota with antibiotics exacerbates acute vascular rejection. Transplantation, 102(7):1085-1095
- Lee M, Wang C, Jin SW, Beischlag TV, Brockman MA, Choy JC. (2019) Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia inducible factor. Free Radic Biol Med., 130:278-287
- Rey K and Choy JC. (2019) Immunologic effects of the microbiota in organ transplantation. Clin Lab Med., 39(1):185-195
- Marzancola M, Haroun S, Choy J, Li P. (2019) A microfluidic antibody bioarray for fast detection of human interleukins in low sample volumes. Can J Chem., 97(10):737-744
- Montgomery A, Tam F, Gursche C, Cheneval C, Besler K, Enns W, Manku S, Rey K, Hanson P, Rose-John S, McManus BM, Choy JC. (2021) Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells., Am J Physiol Cell Physiol., 320(4):C554-565
- Siren EMJ, Luo HD, Tam F, Montgomery A, Enns W, Moon H, Sim L, Rey K, Guan Q, Wang JJ, Wardell CM, Monajemi M, Mojibian M, Levings MK, Zhang ZJ, Du C, Withers SG, Choy JC, Kizhakkedathu JN. (2021) Prevention of vascular allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers. Nat Biomed Eng., 5(10):1202-1216
