We are interested in organismal development, in particular epithelial and synaptic development, and use the fruit fly Drosophila as a model system.
The development of a multicellular organism is an incredibly complex process, and we focus on two aspects, tissue morphogenesis and formation of the nervous system. The morphogenesis of epithelial tissues sculpts an organism into its final form, and we study epithelial morphogenesis in the ovary and the embryo. This work may aid in understanding common birth defects, as well as provide clues as to why so many cancers are derived from epithelial cells. We are also interested in the formation and regulation of synapses at the neuromuscular junction, work that may provide insights into the causes of neurodegenerative diseases.
For more information, visit our research lab website.
- Reed B. and Harden N. (2017) Studying nonproliferative roles for Egfr signaling in tissue morphogenesis using dorsal closure of the Drosophila embryo. Methods Mol Biol.
- Harden, N., Wang, S.J. and Krieger, C. (2016). Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses. J. Cell Sci.
- Krieger, C., Wang, S.J., Yoo, S. H. and Harden, N. (2016). Adducin at the neuromuscular junction in amyotrophic lateral sclerosis: hanging on for dear life. Front. Cell. Neurosci.
- Wang, S., Yoo, S., Kim, H. Y., Wang, M., Zheng, C., Parkhouse, W., Krieger, C. and Harden N. (2015). Detection of in situ protein-protein complexes at the Drosophila larval neuromuscular junction using proximity ligation assay. J. Vis.