Selected Recent Publications:
- Wei, H.-C., Sanny, J., Shu, H., Baillie, D. L. , Brill, J. A., Price, J.
V. and Harden, N. (2003). The Sac1 lipid phosphatase regulates cell shape
change and the JNK cascade during dorsal closure in Drosophila. Curr. Biol.,
in press.
- Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J. L. and Giangrande,
A. (2003). CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links
the Rac1 GTPase pathway to the Fragile X protein. Neuron 38: 887-898.
- Harden, N. (2002). Signaling pathways directing the movement and fusion
of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation
70:181-203.
- Sem, K.P., Zahedi, B., Tan, I., Deak, M., Lim, L., and Harden, N. (2002).
ACK family tyrosine kinase activity is a component of Dcdc42 signaling during
dorsal closure in Drosophila melanogaster. Mol. Cell. Biol. 22:3685-97.
- Harden, N., Ricos, M., Yee, K., Sanny, J., Langmann, C., Yu, H., Chia, W.,
and Lim, L. (2002). Drac1 and Crumbs participate in amnioserosa morphogenesis
during dorsal closure in Drosophila. J Cell Sci. 115:2119-29.
- Hing, H., Xiao, J., Harden, N., Lim, L., and S. L. Zipursky. (1999). Pak
functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila.
Cell 97: 853-863.
- Ricos, M., Harden, N., Sem, K. P., Lim, L. and Chia, W. (1999). Dcdc42 acts
in TGF- signaling during Drosophila morphogenesis: distinct roles for the
Drac1/JNK and Dcdc42/TGF- cascades in cytoskeletal regulation. J. Cell
Sci. 112: 1225-1235.
- Harden, N., Ricos, M., Ong, Y. M., Chia, W. and Lim, L. (1999). Participation
of small GTPases in dorsal closure of the Drosophila embryo: distinct roles
for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci.
112: 273-284.
- Crawford, J. M., Harden, N., Leung, T., Lim, L., and Kiehart, D. P. (1998).
Cellularization in Drosophila melanogaster is disrupted by the inhibition
of Rho activity and the activation of Cdc42 function. Dev. Biol. 204:
151-164.
- Harden, N., Lee, J., Loh, H.-Y., Ong, Y.-M., Tan, I., Leung, T., Manser,
E., and Lim, L. (1996). A Drosophila homolog of the Rac- and Cdc42-activated
serine/threonine kinase PAK is a potential focal adhesion and focal complex
protein that colocalizes with dynamic actin structures. Mol. Cell. Biol.
16: 1896-1908.
- Harden, N., Loh, H. Y., Chia, W., and Lim, L. (1995). A dominant inhibitory
version of the small GTP-binding protein Rac disrupts cytoskeletal structures
and inhibits developmental cell shape changes in Drosophila. Development
121: 903-914.
Last updated 10/08/2003