Fall 2015 - MBB 402 D100
Developmental Biology of Cell Signalling (3)
Class Number: 6888
Delivery Method: In Person
Aspects of developmental biology in the context of signal transduction pathways. The diverse mechanisms used in sell signalling and how the various approaches to the study of signal transduction in organismal development complement each other will be examined with an emphasis on current literature.
In this lecture/seminar course, we will examine select aspects of developmental and cellular biology with a focus on signal transduction. Signaling pathways control a wide range of cellular processes and the characterization of these pathways is having a major impact on cell biology, developmental biology and medicine. In this course, we shall be examining the current literature in this rapidly developing field. We will look at how a combination of biochemistry, cell biology and genetics is being used to investigate the diverse mechanisms used in cell signaling, and examine how the various approaches to studying signal transduction compliment each other.
Specific Topics will include:
- Introduction: mechanisms of signal transduction, approaches available for studying signal transduction
- Signaling pathways involving small GTPase and trimeric G proteins
- Signaling by proteolytic cleavages
- Wnt and Hedgehog signaling pathways
- Regulation of signaling by Kinases and Phosphatases
- Other topics as time permits
- Midterm Exam 20%
- Oral Presentation 25%
- Class Participation 15%
- Final Term Paper 40%
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