Overview

Description

CALENDAR DESCRIPTION:

A detailed examination of the physiology and pathophysiology of the cardiac, vascular and respiratory systems. The course focuses on integration of physiological mechanisms at the molecular, cellular and systems levels. Students with credit for KIN 305 may not take this course for further credit.

COURSE DETAILS:

This course is an advanced course in cardiovascular and respiratory physiology. The information learned in BPK(KIN) 205 is the starting point for discussions about these systems. Students are encouraged to review their BPK(KIN) 205 notes prior to the start of the BPK 305 lectures.

CANVAS:
Canvas, SFU’s learning management system, will be used extensively to provide you with pre-lecture materials, lecture hand outs, quizzes, electronic submission of assignments and grading. I will typically inform the class via email when new content is posted on Canvas, however, it is ultimately your responsibility to monitor Canvas for relevant course material and activities. I strongly suggest that all students adjust their Canvas Notifications to receive a daily update by email for Due Dates, Course Content, File, Announcements and Late Grading.

STUDENT RESPONSE SYSTEM:
In this offering of BPK305 we will use the i>Clicker student response system. Students will be required to have an i>Clicker2 or i>Clicker+. i>Clicker registration will be administered via Canvas. Consequently, students should NOT register their devices at iClicker.com, and students purchasing second hand devices will not be required to pay any registration fees.

DETAILED LECTURE SCHEDULE:
Lecture 1 Constituents of blood
Lecture 2 Cardiac contractile elements
Lecture 3 Regulation of cardiac contraction
Lecture 4 Ionic basis of the cardiac action potential
Lecture 5 Initiation of the cardiac action potential
Lecture 6 The electrocardiogram
Lecture 7 Excitation-contraction coupling
Lecture 8 Cardiac cycle and metabolism
Lecture 9 Arterial vasculature
Lecture 10 Vascular smooth muscle
Lecture 11 Regulation of vascular smooth muscle
Lecture 12 Capillaries, lymphatics and veins
Lecture 13 Venous return
Lecture 14 Special circulations
Lecture 15 Foetal circulation
Lecture 16 Regulation of blood pressure I
Lecture 17 Regulation of blood pressure II
Lecture 18 Cardiovascular adjustments to exercise
Lecture 19 Atherosclerosis I
Lecture 20 Atherosclerosis II
Lecture 21 Myocardial ischaemia – pathology
Lecture 22 Myocardial ischaemia – etiology
Lecture 23 Organisation of the respiratory system
Lecture 24 Mechanics of breathing I
Lecture 25 Mechanics of breathing II
Lecture 26 Pulmonary function testing
Lecture 27 Ventilation perfusion I
Lecture 28 Ventilation perfusion II
Lecture 29 Gas exchange
Lecture 30 Gas transport
Lecture 31 Acid-base regulation
Lecture 32 Control of ventilation I
Lecture 33 Control of ventilation II
Lecture 34 Review

COURSE-LEVEL EDUCATIONAL GOALS:

• define the basic constituents of blood and explain the functional role of the main classes of blood components
• define the basic constituents of blood and explain the functional role of the main classes of blood components
• define the molecular and structural determinants responsible for the contractile properties of cardiac muscle
• explain how cardiac muscle function is physiologically regulated
• explain the role of ion channels in the initiation and propagation of cardiac action potentials and their modulation by the autonomic nervous system
• relate features of the electrocardiogram to physiological propagation of action potentials across the heart
• demonstrate an understanding of the integrated regulation of cardiac output, stroke volume and heart rate at the molecular, cellular and system level through neuronal, humoral and mechanical mechanisms
• explain the principle of / recognize the core parameters of common cardiovascular tests
• describe how cardiac muscle is suited to the metabolism of fat as an energy source and how this dictates the need for tight regulation of coronary blood flow
• define the cellular and molecular properties and function of the various vessel within the vascular tree
• explain the neural, metabolic, myogenic and humoral regulation of vascular tone by smooth muscle and endothelial cells at the molecular, cellular and system levels
• distinguish the concepts of auto-regulation, capacitance, resistance and compliance as control mechanisms that regulate blood flow at the systemic and regional level
• use vascular- and cardiac-function curves to illustrate the intrinsic matching of venous return and cardiac output
• explain how venous return and cardiac output are maintained at steady state levels
• apply Ohm's and Poiseuille's Laws to the regulation of mean arterial pressure
• explain the acute and chronic regulation of blood pressure through neural, paracrine, humoral and renal mechanisms
• apply Fick’s Law to explain the exchange of fluids, metabolites and gases across capillary and alveolar membranes
• consider special circulatory adaptations including those of skin, muscle, brain, fetus and neonate, and kidney
• explain how the circulatory system adapts to acute and repeated exercise
• explain the etiology and cellular and molecular pathology of atherosclerosis and its consequences in terms of myocardial ischemia and infarct
• describe mechanisms of pathophysiological perturbations of blood pressure control, their consequences and treatment
• describe the structure and function of respiratory system components at moelcular, cellular and systems levels
• explain how the mechanical properties of the lungs influence respiration
• explain the principle of / recognize the core parameters of common respiratory tests
• discuss the regulation of ventilation and perfusion, how they are matched, and the consequences of a mismatch
• explain the exchange and transport of blood gases at the lung and tissue interfaces
• understand the concept of acid-base balance and how this is achieved
• describe central and peripheral ventilatory control mechanisms
• discuss the pathological basis for common respiratory disorders

Grading

Materials

REQUIRED READING: