Fall 2017 - MBB 426 D100

Immune System I: Basis of Innate and Adaptive Immunity (4)

Class Number: 3754

Delivery Method: In Person


  • Course Times + Location:

    Mo 2:30 PM – 3:20 PM
    AQ 3159, Burnaby

    We 2:30 PM – 4:20 PM
    BLU 9021, Burnaby

    Fr 2:30 PM – 3:20 PM
    BLU 9660, Burnaby

  • Exam Times + Location:

    Dec 9, 2017
    8:30 AM – 11:30 AM
    AQ 3005, Burnaby

  • Prerequisites:

    MBB 331 with a minimum grade of C.



The basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate, antibody and cellular immune responses and their control, and development of the cells involved in these responses. Students who have taken HSCI 325 or HSCI 426 cannot take MBB 426 for further credit.


This course covers the basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate and adaptive antibody and cellular immune responses will be covered and their control, and development of the cells involved in these responses. Students will explore the primary literature in immunology.

4 lecture hours/week; 1 tutorial hour/week; 0 lab hours

Lecture Schedule

Lectures Topic Chapters
1-2 Properties and Overview of Immune Responses 1
3-4 Innate Immunity: The First Lines of Defense 2
5-6 The Induced Responses of Innate Immunity 3
7-8 Antigen Recognition by B-cell and T-cell Receptors 4
9-10 The Generation of Lymphocyte Antigen Receptors 5
11-12 Antigen Presentation to T Lymphocytes 6
13-14 Signaling through Immune System Receptors 7
15-16 The Development and Survival of Lymphocytes I 8
17-18 The Development and Survival of Lymphocytes II 8
19-20 T-cell Mediated Immunity 9
21-22 The Humoral Immune Response 10
23-24 Dynamics of Adaptive Immunity 11
25-26 The Mucosal Immune System 12


  • 5 non-cumulative exams (210 points) 70%
  • Weekly clicker quizzes (15 points) 5%
  • Weekly in-class problem solving activities (15 points) 5%
  • Presentation & summary (50 points) 16.7%
  • Tutorial participation (10 points) 3.3%


The textbook is required for this course, as are attendance and participation in the in-class activities and tutorials.



Please bring your iClicker to your first tutorial so that it can be registered.
Dates of iClicker tests for each chapter will be provided in the full syllabus.


A. K. Abbas et al., Cellular and Molecular Immunology, 9th Ed., Elsevier Inc. 2017. https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3
ISBN: 978-0323479783


Those interested in medicine & clinical sciences might like the companion text: R. Geha & L. Notarangelo. Case Studies in Immunology. 7th Ed. 2016. Garland Publishing.
ISBN: 9780815345121

A good reference is Alberts et al., Molecular Biology of the Cell (5th or 6th Ed), 2014 or 2007, respectively, Garland Science, New York.

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html