Simon Fraser University
Engaging the World

Course Outlines

Fall 2018 - MBB 426 D100

Immune System I: Basis of Innate and Adaptive Immunity (4)

Class Number: 3548

Delivery Method: In Person

Overview

  • Course Times + Location:

    Sep 4 – Dec 3, 2018: Mon, 2:30–3:20 p.m.
    Burnaby

    Sep 4 – Dec 3, 2018: Wed, 2:30–4:20 p.m.
    Burnaby

    Sep 4 – Dec 3, 2018: Fri, 2:30–3:20 p.m.
    Burnaby

  • Prerequisites:

    MBB 331 with a minimum grade of C, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

Basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system; structure and function of lymphoid tissues. Development of cells and tissues involved in immune responses. Innate and adaptive antibody and cellular immune responses and their orchestration, including mucosal immunity. Students with credit for HSCI 426 may not take this course for credit.

COURSE DETAILS:

This course covers the basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate and adaptive antibody and cellular immune responses will be covered and their control, and development of the cells involved in these responses. Students will explore the primary literature in immunology.

4 lecture hours/week; 1 tutorial hour/week; 0 lab hours

Lecture Schedule

Lectures Topic Chapters
1 Properties and Overview of Immune Responses 1
2-3 Cells & Tissues of the Immune System 2
4-5 Leukocyte Circulation & Migration into Tissues 3
6-8 Innate Immunity 4
9-10 Antibodies & Antigens 5
11-12 MHC & Antigen Presentation to T cells 6
13-14 Immune Receptors & Signal Transduction 7
15 B-lymphocyte Development & Antigen-receptor Gene Rearrangement 8
16 Overview of Tolerance & B-lymphocyte Tolerance 15
17-18 T-lymphocyte Development and Tolerance 8 & 15
19 Activation of T cells 9
20 Differentiation & Functions of CD4+ T-effector Cells 10
21 Differentiation & Functions of CD8+ T-effector Cells 11  
22-23  B-cell Activation & Antibody Production 12
24-25  Effector Mechanisms of Humoral immunity 13
26-27  Specialized Immunity at Epithelial Barriers & in Immune Privileged Tissues 14

Grading

  • 5 non-cumulative exams (210 points) 70%
  • Weekly clicker quizzes (15 points) 5%
  • Weekly in-class problem solving activities (15 points) 5%
  • Presentation & summary (50 points) 16.7%
  • Tutorial participation (10 points) 3.3%

REQUIREMENTS:

The textbook is required for this course, as are attendance and participation in the in-class activities and tutorials.

Materials

MATERIALS + SUPPLIES:

Please bring your iClicker to your first tutorial so that it can be registered.
Dates of iClicker tests for each chapter will be provided in the full syllabus.

REQUIRED READING:

A. K. Abbas et al., Cellular and Molecular Immunology, 9th Ed., Elsevier Inc. 2017. https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3
ISBN: 978-0323479783

RECOMMENDED READING:

Those interested in medicine & clinical sciences might like the companion text: R. Geha & L. Notarangelo. Case Studies in Immunology. 7th Ed. 2016. Garland Publishing.
http://www.garlandscience.com/product/isbn/9780815345121
ISBN: 9780815345121

A good reference is Alberts et al., Molecular Biology of the Cell (5th or 6th Ed), 2014 or 2007, respectively, Garland Science, New York.

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
    http://www.lib.sfu.ca/help/tutorials/plagiarism-tutorial
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
    http://learningcommons.sfu.ca/
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS