Spring 2018 - MBB 342 D100

Introductory Genomics and Bioinformatics (3)

Class Number: 3751

Delivery Method: In Person


  • Course Times + Location:

    We 12:30 PM – 2:20 PM
    SWH 10041, Burnaby

  • Exam Times + Location:

    Apr 21, 2018
    12:00 PM – 3:00 PM
    AQ 3003, Burnaby

  • Prerequisites:

    MBB 231, BISC 202 and 3 units of CMPT or equivalent, with a minimum grade of C.



Major topics in genomics and bioinformatics, with integrated discussion of associated ethical/legal/social issues. An overview of laboratory and computer-based methods to study genomes, and their applications. Hands-on computer lab session providing an opportunity to use and experiment with bioinformatics software and databases utilized in genomics and bioinformatics research.


Course Structure:

Approximately one week will be devoted to each of the following topics:

  1. What is Bioinformatics? What is Genomics? An overview and history
  2. Obtaining the data: Genome sequencing, genome assembly
  3. Organizing the data: Gene/genome databases, browsers and searching
  4. Sequence alignment and sequence similarity search
  5. Genome assembly and short read mapping
  6. Human genome variation – SNP, copy number and structural
  7. Transcriptomics/RNA sequencing, chromatin IP and promoter analysis
  8. Multiple sequence alignment, intro to evolutionary analysis
  9. Orthologs, paralogs/gene families, phylogenetic analysis
  10. Protein, network-based analysis and Systems Biology
  11. Microbial genomics and metagenomics of environmental/human microbiomes
  12. Human genomics and personalized medicine
  13. Plant and animal genomics in agriculture and aquaculture


  • Lab assignments 40%
  • Final written exam 40%
  • Lab assignment/project 20%


Written work for this course will be submitted via Turnitin, a third party service licensed for use by SFU. Turnitin is used for originality checking to help detect plagiarism. Students will be required to create an account with Turnitin, and to submit their work via that account, on the terms stipulated in the agreement between the student and Turnitin. This agreement includes the retention of your submitted work as part of the Turnitin database. Any student with a concern about using the Turnitin service may opt to use an anonymous identity in their interactions with Turnitin. Students who do not intend to use Turnitin in the standard manner must notify the instructor at least two weeks in advance of any submission deadline. In particular, it is the responsibility of any student using the anonymous option (i.e. false name and temporary e-mail address created for the purpose) to inform the instructor such that the instructor can match up the anonymous identity with the student.

Department Undergraduate Notes:

  • Students are advised to review the plagiarism tutorial found at
  • For help with writing, learning and study strategies please contact the Student Learning Commons at
  • Students requiring accommodations as a result of a disability, must contact the Centre for Students with Disabilities (778-782-3112 or e-mail:  csdo@sfu.ca)

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html