Spring 2018 - MBB 727 G100
Immune System II: Immune Responses in Health and Disease (3)
Class Number: 3764
Delivery Method: In Person
Immunological responses towards bacterial, viral and parasitic infections. The basis of vaccines, primary immunodeficiencies, and the mechanisms by which the immune system causes allergy, autoimmune diseases, and organ transplant rejection. Immune responses towards cancer and therapeutic modulation of immune responses to protect against the indicated diseases will also be discussed. Students with credit for MBB 427, HSCI 427, or HSCI 727 may not complete MBB 727 for credit.
Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunodeficiencies, HIV infection, asthma and allergy, autoimmunity, and organ transplantation. Immune responses to cancer and cancer immunotherapy will also be discussed.
1. Evasion and subversion of host defenses by pathogens
2. Mechanism of action of vaccines
3. Primary immunodeficiencies
4. Acquired immunodeficiency
5. Allergy and hypersensitivity
6. Physiological induction and maintenance of tolerance
9. Tumor immunology and immunotherapy
- Non-cumulative exams (2 x 30%) 60%
- One individual in-class presentation with written summary 30%
- Class participation 10%
Original research articles and review articles
A. K. Abbas et al., Cellular and Molecular Immunology, 9th Ed., Elsevier Inc. 2017. https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3
Graduate Studies Notes:
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