Spring 2018 - MBB 727 G100

Immune System II: Immune Responses in Health and Disease (3)

Class Number: 3764

Delivery Method: In Person


  • Course Times + Location:

    We, Fr 2:30 PM – 4:20 PM
    BLU 10021, Burnaby

  • Prerequisites:

    MBB 426 or HSCI 426 or permission of the instructor.



Immunological responses towards bacterial, viral and parasitic infections. The basis of vaccines, primary immunodeficiencies, and the mechanisms by which the immune system causes allergy, autoimmune diseases, and organ transplant rejection. Immune responses towards cancer and therapeutic modulation of immune responses to protect against the indicated diseases will also be discussed. Students with credit for MBB 427, HSCI 427, or HSCI 727 may not complete MBB 727 for credit.


Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunodeficiencies, HIV infection, asthma and allergy, autoimmunity, and organ transplantation. Immune responses to cancer and cancer immunotherapy will also be discussed.

Lecture Topics
1.      Evasion and subversion of host defenses by pathogens
2.      Mechanism of action of vaccines
3.      Primary immunodeficiencies
4.      Acquired immunodeficiency
5.      Allergy and hypersensitivity
6.      Physiological induction and maintenance of tolerance
7.      Autoimmunity
8.      Transplantation
9.      Tumor immunology and immunotherapy


  • Non-cumulative exams (2 x 30%) 60%
  • One individual in-class presentation with written summary 30%
  • Class participation 10%



Original research articles and review articles

A. K. Abbas et al., Cellular and Molecular Immunology, 9th Ed., Elsevier Inc. 2017. https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3
ISBN: 9780323479783

Graduate Studies Notes:

Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.

Registrar Notes:

SFU’s Academic Integrity web site http://students.sfu.ca/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html