Fall 2019 - MBB 829 G100
Special Topics in Biochemistry (3)
Class Number: 1989
Delivery Method: In Person
Consideration of recent literature concerning selected contemporary research topics. Can be taken more than once with permission of the instructor.
An examination of the genomic changes that accrue during the formation and treatment of human cancer.
The course will examine the role that genetic mutations play in the development of human cancer and tumour formation. We will study the spectrum of different types of genetic alterations that accrue and their distribution across different cancer types. We will study the technologies that allow these changes to be detected and how they are interpreted clinically. The course will explore how different mutations can be correlated with specific therapeutics and how further genetic mutations can lead to treatment resistance.
- Cancer sequencing
- Tumour heterogeneity
- DNA repair
- Hereditary cancer
- Treatment resistance
- Neo-antigens and immunotherapy
- Cancer epigenomics
- Personalized oncogenomics
- Mutational signatures
- In-class presentation 30%
- Writing assignment 50%
- Class participation 20%
The Biology of Cancer, 2nd Ed, Robert A. Weinberg, 2014, Garland Publishing (for background reading).
Graduate Studies Notes:
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Each student is responsible for his or her conduct as it affects the University community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html
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