Spring 2019 - STAT 854 G100
Biometrics: Methods in Biomedical Studies (4)
Class Number: 3459
Delivery Method: In Person
Principles, methods and applications of basic statistical approaches in biomedical studies are presented. Topics include introduction to epidemiology; design of cohort and case-control studies; experimental versus observational data, and cross-sectional versus longitudinal studies; issues of confounding, causation and missing data; design of clinical trials; data monitoring and interim analysis.
- History of epidemiology, and commonly-used concepts and terminology in biomedical studies
- Measures of disease occurrence and association.
- Design of medical studies: cohort and case-control studies; controlled clinical experiments.
- Models and analysis in prospective and retrospective studies.
- Confounding, causal diagrams, and missing data.
- Clinical trial design principles: bias control, random error control, randomization, blocking, masking
- Types of clinical trials: phases of trial, translational, dose-finding, cross-over, safety and efficacy, and comparative trials.
- Study monitoring: sequential methods.
- Assignments 40%
- Projects 50%
- Class Participation 10%
All grading is subject to change.
Epidemiologic Methods: Studying the Occurrence of Illness, 2nd ed. Authors: Noel S. Weiss and Thomas D. Koepsell. Publisher: Oxford University Press
Clinical Trials: A Methodologic Perspective, Second Edition. Author: Steven Piantadosi. Publisher: Wiley
Fundamentals of Clinical Trials, 5th ed. Authors: L.M. Friedman, C.D. Furberg, D. DeMets, D.M. Reboussin, C.B. Granger. Publisher: Springer
Graduate Studies Notes:
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