Summer 2019 - MBB 702 G100
Developmental Biology of Cell Signalling (3)
Class Number: 5243
Delivery Method: In Person
Aspects of developmental and cellular biology in the context of signal transduction pathways. The diverse mechanisms used in cell signalling and how the various approaches to the study of signal transduction in organismal development complement each other will be examined with an emphasis on current literature.
In this lecture/seminar course, we will examine select aspects of developmental and cellular biology with a focus on signal transduction. Signaling pathways control a wide range of cellular processes and the characterization of these pathways is having a major impact on cell biology, developmental biology and medicine. In this course, we shall be examining the current literature in this rapidly developing field. We will look at how a combination of biochemistry, cell biology and genetics is being used to investigate the diverse mechanisms used in cell signaling, and examine how the various approaches to studying signal transduction compliment each other.
Specific Topics will include:
1. Introduction: mechanisms of signal transduction, approaches available for studying signal transduction
2. Signaling pathways involving small GTPase and trimeric G proteins
3. Signaling by proteolytic cleavages
4. Wnt and Hedgehog signaling pathways
5. Regulation of signaling by Kinases and Phosphatases
6. Other topics as time permits
- Two oral presentations 45%
- Class participation 15%
- Term paper 40%
We will read review articles and primary research papers only. A basic development textbook may be used by students as a refresher on certain topics.
Students who have taken MBB 437 or MBB 737 may not enroll in this course.
Graduate Studies Notes:
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