Spring 2020 - HSCI 321 D100

Human Pathophysiology (3)

Class Number: 2169

Delivery Method: In Person


  • Course Times + Location:

    Mo 9:30 AM – 12:20 PM
    AQ 3153, Burnaby

  • Exam Times + Location:

    Apr 24, 2020
    8:30 AM – 11:30 AM
    EDB 7618, Burnaby

  • Prerequisites:

    MBB 231, or permission of the instructor.



Molecular, cellular and systemic approach to examine topics in human pathophysiology.


This course will provide an introduction to topics in the pathophysiological mechanisms of disease. In order to provide a foundation to explore human pathophysiology, this course will transfer topics of cellular and molecular biology to understand human physiology at the systemic level. Functional human anatomy will be described when necessary to understand essential concepts. This course is designed to prepare undergraduates who have an interest in medicine and human health services to pursue careers in these disciplines. In addition, this course will support the Bachelor of Science in the Faculty of Health Sciences and may be of interest to students in others faculties including Science (BISC, BPK, MBB).
Each section/topic of the course will include an examination of the molecular and cellular biology involved and provide specific examples of human disorders detailing how these processes are implicated in the pathophysiology of disease. Specifically, we will examine pathologies associated with cohesinopathies, which represent a collection of diseases presenting a wide range of pathologies of varying severity that stems from genetic and unknown environmental determinants. This approach will give us an organizing principle and enable us to focus on the function and malfunction of specific body systems. These include: · Cardiovascular system ·  Respiratory system ·  Gastrointestinal system ·  Renal system ·  Nervous system · Endocrine system


Upon the completion of this course students should be familiar with fundamental principles of human physiology and to be able to explain several biological mechanisms governing disease pathogenesis in humans.
At the end of this course, the students should have a basic overview of human physiology and be able to demonstrate and exemplify differences arising from disease states, including skills in diagnosing case studies and recognizing disease risk factors and outcomes.
In addition, this course should leave the students with the appropriate understanding and background to proceed to more intensive and comprehensive courses in the Life Sciences.


  • Midterm Exam 1 20%
  • Midterm Exam 2 20%
  • Final Exam 20%
  • Questions and Answers 10%
  • Case Study 10%
  • Wiki page 20%


A subscription to Tophat service or app is required.  https://tophat.com/



Tophat subscription.  Available at https://tophat.com/ or at SFU bookstore, ISBN 978-0986615108.


Guyton and Hall. Textbook of Medical Physiology. 11th or 12th Ed. Elsevier
ISBN: 978-1-4160-4574-8

Robbins & Cotran. Pathologic Basis of Disease. 7th or 8th Ed.

ISBN: 978-1-4160-3121-5

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html