Spring 2020 - HSCI 427 D100
Immune System II: Immune Responses in Health and Disease (3)
Class Number: 2186
Delivery Method: In Person
Course Times + Location:
We, Fr 2:30 PM – 4:20 PM
AQ 3153, Burnaby
Prerequisites:MBB 326 or HSCI 326, with a minimum grade of C, or permission of the instructor.
Defects in the immunologic responses to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for MBB 427 may not take this course for credit.
Many diseases are caused by dysregulation of the immune system. This course will examine the immunological mechanisms underlying human immunodeficiencies, infection, asthma and allergy, autoimmunity, and organ transplantation. Immune responses to cancer and cancer immunotherapy will also be discussed. The course will emphasize recent scientific literature and encourage all students to undertake an independent investigation of recent advances related to the field of immunology.
- Review of innate and adaptive immunity
- Evasion and subversion of host defenses by pathogens
- Mechanism of action of vaccines
- Primary immunodeficiencies
- Acquired immunodeficiency
- Allergy and hypersensitivity
- Physiological induction and maintenance of tolerance
- Tumor immunology and immunotherapy
- 2 non-cumulative exams (20% each) 40%
- 2 in-class presentations with written summaries (20% each) 40%
- Quizzes 10%
- Attendance and participation 10%
Original research articles and review articles
The Immune System, 4th Ed., Peter Parham, 2015. Garland Science.
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