Spring 2020 - HSCI 427 D100

Immune System II: Immune Responses in Health and Disease (3)

Class Number: 2186

Delivery Method: In Person


  • Course Times + Location:

    We, Fr 2:30 PM – 4:20 PM
    AQ 3153, Burnaby

  • Prerequisites:

    MBB 326 or HSCI 326, with a minimum grade of C, or permission of the instructor.



Defects in the immunologic responses to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for MBB 427 may not take this course for credit.


Course Description

Many diseases are caused by dysregulation of the immune system.  This course will examine the immunological mechanisms underlying human immunodeficiencies, infection, asthma and allergy, autoimmunity, and organ transplantation.  Immune responses to cancer and cancer immunotherapy will also be discussed.  The course will emphasize recent scientific literature and encourage all students to undertake an independent investigation of recent advances related to the field of immunology.

Lecture Topics

  1. Review of innate and adaptive immunity
  2. Evasion and subversion of host defenses by pathogens
  3. Mechanism of action of vaccines
  4. Primary immunodeficiencies
  5. Acquired immunodeficiency
  6. Allergy and hypersensitivity
  7. Physiological induction and maintenance of tolerance
  8. Autoimmunity
  9. Transplantation
  10. Tumor immunology and immunotherapy


  • 2 non-cumulative exams (20% each) 40%
  • 2 in-class presentations with written summaries (20% each) 40%
  • Quizzes 10%
  • Attendance and participation 10%



Original research articles and review articles


The Immune System, 4th Ed., Peter Parham, 2015. Garland Science.
ISBN: 978-0-8153-4466-7

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html