Spring 2020 - HSCI 727 G100

Immune System II: Immune Responses in Health and Disease (3)

Class Number: 7055

Delivery Method: In Person


  • Course Times + Location:

    We, Fr 2:30 PM – 4:20 PM
    AQ 3153, Burnaby

  • Prerequisites:

    MBB/HSCI 426 or permission of the instructor.



The immunologic response to bacterial, viral and parasitic infections, immunological diseases, such as autoimmune diseases, immunodeficiency, hypersensitivity reactions (including asthma and allergy) and transplantation-rejection reactions. Immunotherapeutics and vaccine development. Students with credit for MBB 427, HSCI 427 or MBB 727 may not complete HSCI 727 for credit.


Course Description

Many diseases are caused by dysregulation of the immune system.  This course will examine the immunological mechanisms underlying human immunodeficiencies, infection, asthma and allergy, autoimmunity, and organ transplantation.  Immune responses to cancer and cancer immunotherapy will also be discussed.  The course will emphasize recent scientific literature and encourage all students to undertake an independent investigation of recent advances related to the field of immunology.

Lecture Topics

  1. Review of innate and adaptive immunity
  2. Evasion and subversion of host defenses by pathogens
  3. Mechanism of action of vaccines
  4. Primary immunodeficiencies
  5. Acquired immunodeficiency
  6. Allergy and hypersensitivity
  7. Physiological induction and maintenance of tolerance
  8. Autoimmunity
  9. Transplantation
  10. Tumor immunology and immunotherapy


  • 2 non-cumulative exams (10% each) 20%
  • 2 in-class presentations with written summaries (30% each) 60%
  • Quizzes 10%
  • Attendance and participation 10%



Original research articles and review articles


The Immune System, 4th Ed., Peter Parham, 2015. Garland Science.
ISBN: 978-0-8153-4466-7

Graduate Studies Notes:

Important dates and deadlines for graduate students are found here: http://www.sfu.ca/dean-gradstudies/current/important_dates/guidelines.html. The deadline to drop a course with a 100% refund is the end of week 2. The deadline to drop with no notation on your transcript is the end of week 3.

Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html