# Spring 2020 - STAT 305 D100

## Overview

• #### Course Times + Location:

Mo 2:30 PM – 4:20 PM
RCB IMAGTH, Burnaby

We 2:30 PM – 3:20 PM
SSCB 9200, Burnaby

• #### Exam Times + Location:

Apr 14, 2020
12:00 PM – 3:00 PM
Location: TBA

• #### Instructor:

Jorge Rodriguez
• #### Prerequisites:

One of STAT 201, STAT 203, STAT 205, STAT 270, or BUEC 232.

## Description

#### CALENDAR DESCRIPTION:

Intermediate statistical techniques for the health sciences. Review of introductory concepts in statistics and probability including hypothesis testing, estimation and confidence intervals for means and proportions. Contingency tables and the analysis of multiple 2x2 tables. Correlation and regression. Multiple regression and model selection. Logistic regression and odds ratios. Basic concepts in survival analysis. This course may not be used to satisfy the upper division requirements of the Statistics major or honours program. Quantitative.

#### COURSE DETAILS:

STAT Workshop Coordinator: Marie Loughin

Outline:

This upper-division course provides an opportunity for the further development of analytic skills acquired in basic courses in statistics and the health sciences. It concentrates on the relatively few techniques that are currently most used in health research, but it also seeks to provide a conceptual basis for understanding other techniques. The course focuses on unifying principles and widely applicable methods as opposed rote memorization of an array of unrelated ad-hoc procedures. The material is presented descriptively, from the point of view of understanding and practical use.

The emphasis of the course is on analysis (rather than design) of observational studies where there is one outcome variable of primary interest and where the data are made up of multiple independent observations. Important areas not covered are: classical multivariate analysis (e.g., factor analysis, discriminant analysis, etc.), longitudinal data analysis, time series, random effects models, and experimental design considerations (e.g., Latin squares, etc.).

Objectives:

By the end of the course the participant should:

1. understand the concept of a statistical model and how such models correspond to specific hypotheses or questions,
2. be able to interpret the results of an analysis in relation to the original questions or hypotheses that motivated the analysis,
3. be familiar with data analysis methods commonly used in health sciences and understand the basic limitations of competing methods,
4. understand and be able to critique the analysis methods described in published health research papers,
5. be able to communicate effectively with statistical consultants.

Topics:

The scheduling of the following topics is approximate:

1. Review of introductory statistics from the pre-requisite course: Hypothesis testing, estimation and confidence intervals for means and proportions.
2. Review of basic concepts of probability with applications including diagnostic testing, sensitivity and specificity, the relative risk and the odds ratio.
3. Contingency Tables: The Chi-square test, r x c tables, multiple 2x2 tables, Simpson's paradox, Mantel- Haenszel method.
4. Correlation and simple linear regression: Regression concepts, estimation and testing for regression coefficients, evaluation of the model.
5. Multiple linear regression: Inference for regression coefficients, confounding and interaction, indicator variables, model selection, prediction, model assumptions and checking.
6. Logistic regression: Odds ratios, inference for regression coefficients, model assumptions, case-control studies.
7. Time permitting: Survival analysis including life tables, censoring, Kaplan-Meier method, log-rank test.

• Assignments 8%
• Midterm 1 23%
• Midterm 2 23%
• Final Exam 46%

#### NOTES:

Above grading is subject to change.

Use of cell phone and computers in class:
Cell phones should be turned off and put away during classes and exams. Use of computers in class should be limited to active participation in taking notes.

## Materials

Required Textbook:

Principles of Biostatistics (2nd ed.) by M. Pagano, K. Gauvreau. Publisher: Brooks/Cole and CRC Press

ISBN: 9780534229023

The e-book is also available for purchase from the CRC press website:
https://www.crcpress.com/Principles-of-Biostatistics-Second-Edition/Pagano-Gauvreau/p/book/9781138593145

Students with Disabilites:
Students requiring accommodations as a result of disability must contact the Centre for Accessible Learning 778-782-3112 or csdo@sfu.ca

Tutor Requests:
Students looking for a Tutor should visit http://www.stat.sfu.ca/teaching/need-a-tutor-.html. We accept no responsibility for the consequences of any actions taken related to tutors.

#### Registrar Notes:

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html