Fall 2022 - CHEM 755 G100
Synthetic Organic Chemistry (3)
Class Number: 2841
Delivery Method: In Person
An advanced treatment of strategy in organic synthesis. The principles and use of modern synthetic methodology. Equivalent Courses: CHEM751
Please note, this course outline was accurate at the time of publication but is subject to change.
Mode of Instruction:
3 lecture hours/week; 1 tutorial hour/week
Lecture: In-Person, Burnaby Campus
Tutorial: In-Person, Burnaby Campus
An advanced treatment of the strategies and tactics that are used in multi-step organic synthesis will be provided (retrosynthetic analysis, protecting groups, linear and convergent synthesis). The principles and uses of modern synthetic methods will be introduced. The approach employed in this course will be to examine the syntheses of biologically active natural products (steroids, terpenes, alkaloids, and polyethers). This will provide a historical perspective of the development of the art and science of total synthesis over the course of the past century. This approach will also illustrate the use of functional group interconversions, carbon-carbon bond formation reactions, organometallic chemistry, asymmetric synthesis, pericyclic reactions and enzymes in total synthesis.
Combined undergraduate course: CHEM 455 - Synthetic Organic Chemistry (3)
- Oral Presentation 20%
- Midterm Exam 20%
- Final Exam 60%
Laszlo Kurti & Barbara Czako. "Strategic Applications of Named Reactions in Organic Synthesis". 1st Edition, 2005. Publisher: Academic Press.
"Advanced Organic Chemistry. Part A. Structure and Mechanisms. Part B. Reactions and Synthesis", Carey and Sundberg, Plenum Press, 1990.
"Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", March, Wiley 1985.
"The Logic of Chemical Synthesis", Corey and Chang, Wiley, 1989.
"Designing Organic Syntheses: A Programmed Introduction to the Synthon Approach", Warren, Wiley, 1980.
"Organic Synthesis: Concepts Methods, Starting Materials", Fuhrhop and Penzlin, VCH, 1994.
"Classics in Total Synthesis I", Nicolaou and Sorensen, VCH, 1996. (and II, III).
"Classics in Hydrocarbon Chemistry", Hopf, VCH, 2000.
REQUIRED READING NOTES:
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Graduate Studies Notes:
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