Fall 2022 - MBB 331 D100
Molecular Biology (4)
Class Number: 2189
Delivery Method: In Person
Course Times + Location:
Tu, Th 10:30 AM – 12:20 PM
AQ 3005, Burnaby
Exam Times + Location:
Dec 16, 2022
7:00 PM – 10:00 PM
AQ 3181, Burnaby
1 778 782-7140
Prerequisites:MBB 231, and BISC 202, with a minimum grade of C.
The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction.
Molecular biology is a revolution that has transformed the life sciences over the last half century and continues to advance rapidly, bringing with it profound implications for the future of biology, medicine, and agriculture. Our look at molecular biology will extend from the early history and basic principles through to recent developments and future directions. In our consideration of the current status of molecular biology, the emphasis will be placed on examining recent papers in primary scientific journals. Textbooks can only supply information that is current up to several years ago, and we must consider the primary literature to learn about recent advances. Studying the primary literature is also the best way to understand how research in molecular biology is carried out and how the science moves forward. The tutorial project is designed to familiarize you with reading and evaluating a research paper. You will choose a recent paper from any area of modern molecular biology and do a short oral presentation together with a one page summary of the paper. Oral presentations will be followed by a short question and discussion period.
- Introduction: Overview of molecular biology and its history
- Structure and function of nucleic acids
- Recombinant DNA methods
- Replication, recombination and repair
- Prokaryotic gene organization, expression and regulation
- Bacterial viruses
- Eukaryotic gene organization, expression and regulation
- Special topics - to be arranged, but may include functional and personal genomics
- 4 midterms (15% each) 60%
- Online weekly quizzes 10%
- Tutorial problems 5%
- Presentations in tutorials 25%
Molecular Biology: Principles and Practice, 2nd edition, by Michael M. Cox, Jennifer A. Doudna, Michael O'Donnell, W.H. Freeman & Company, 2015. eText also available.
REQUIRED READING NOTES:
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Department Undergraduate Notes:
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- Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail: email@example.com)
ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS
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