Spring 2022 - BPK 420 D100

Selected Topics in Biomedical Physiology and Kinesiology I (3)

hiPSC-CMs & Cardiomyopathie

Class Number: 8296

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 10 – Apr 11, 2022: Tue, 2:30–5:20 p.m.
    Burnaby

  • Prerequisites:

    To be announced in the Undergraduate Schedule of Classes and Examinations found at go.sfu.ca.

Description

CALENDAR DESCRIPTION:

Selected topics in areas not currently offered as formal courses within the undergraduate course offerings in the Department of Biomedical Physiology and Kinesiology. The topics in this course will vary from term to term, depending on faculty availability and student interest.

COURSE DETAILS:

Seminar on Tuesday, 2:30 - 5:20, course will be synchronous but REMOTE


Course Description:

Seminar based exploration of the use of cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) to understand the mechanisms of inherited cardiomyopathies (e.g., HCM - hypertrophic cardiomyopathy, the leading cause of sudden cardiac arrest in youth) and arrhythmias (e.g., CPVT, LQTS).  

 

Course Details:

This course presents a detailed analysis of the causes and development of potential therapies for inherited cardiomyopathies and arrhythmias. Students will be required to adopt a multidisciplinary approach to this inquiry that includes cellular and molecular biomechanics, physiology/biophysics, electrophysiology, biochemistry, molecular biology, and tissue engineering including 3D bioprinting. This course will focus on the technologies involved in the use of human induced pluripotent derived cardiomyocytes (hiPSC-CMs) to study these diseases including genome editing, hiPSC differentiation and maturation, and hiPSC-CM phenotyping. Course structure: three hours of lectures / presentations per week.

COURSE-LEVEL EDUCATIONAL GOALS:

By the end of this course students will be able to: 

  • Critically evaluate molecular cardiac physiology literature 
  • Communicate controversial scientific topics in oral presentations 
  • Challenge basic dogma and conventions within the scientific field 
  • Demonstrate a thorough understanding of the cutting-edge technology used in the field 

Grading

  • 1st Presentation 15%
  • 2nd Presentation 15%
  • 3rd Presentation 15%
  • Final Presentation 25%
  • Term Paper 30%

REQUIREMENTS:

Prereq. BPK 412 (or consent of the Instructor)

Department Undergraduate Notes:

It is the responsibility of the student to keep their BPK course outlines if they plan on furthering their education.

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

TEACHING AT SFU IN SPRING 2022

Teaching at SFU in spring 2022 will involve primarily in-person instruction, with safety plans in place.  Some courses will still be offered through remote methods, and if so, this will be clearly identified in the schedule of classes.  You will also know at enrollment whether remote course components will be “live” (synchronous) or at your own pace (asynchronous).

Enrolling in a course acknowledges that you are able to attend in whatever format is required.  You should not enroll in a course that is in-person if you are not able to return to campus, and should be aware that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes.

Students with hidden or visible disabilities who may need class or exam accommodations, including in the context of remote learning, are advised to register with the SFU Centre for Accessible Learning (caladmin@sfu.ca or 778-782-3112) as early as possible in order to prepare for the spring 2022 term.