Simon Fraser University
Engaging the World

Course Outlines

Spring 2022 - HSCI 427 D100

Immune Responses in Health and Disease (3)

Class Number: 5799

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 10 – Apr 11, 2022: Wed, Fri, 2:30–4:20 p.m.
    Burnaby

  • Prerequisites:

    MBB 326 or HSCI 326, with a minimum grade of C, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

Defects in the immunologic responses to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for MBB 427 may not take this course for credit.

COURSE DETAILS:

Lecture and Reading Schedule

Jan. 12 (Wed) - Overview of immunity, Chapter 1 - 12

Jan. 14 (Fri) – Vaccines: Impact and mechanisms of action, Chapter 11 p. 317 - 344 Jan. 19 (Wed) – Vaccines: Impact and mechanisms of action, Chapter 11 p. 317 - 344

Jan. 21 (Fri) – Evasion of the immune system by pathogens, Chapter 13 p. 375 - 384

Jan. 26 (Wed) – Evasion of the immune system by pathogens, Chapter 13 p. 375 - 384; HIV/AIDS, Chapter 13 p. 395 - 406

Jan. 28 (Fri) – HIV/AIDS, Chapter 13 p. 395 – 406

Feb. 2 (Wed) – Development and maintenance of tolerance: Central tolerance, Chapter 7 p. 202 – 208; T and B cell tolerance, Review article

Feb. 4 (Fri) – Allergic responses Feb. 9 (Wed) – Allergic responses

Feb. 11 (Fri) – Exam I

Feb. 16 (Wed) – Autoimmune diseases: Causes and pathogenic mechanisms, Chapter 16 p. 475 - 502

Feb. 18 (Fri) - Autoimmune diseases: Causes and pathogenic mechanisms, Chapter 16 p. 475 - 502

Feb. 23 &25 – No class: Reading break

Mar. 2 (Wed) - Transplantation: Pathological features, allorecognition, and mechanisms of rejection, Chapter 15 p. 439 - 470

Mar. 4 (Fri) - Transplantation: Pathological features, allorecognition, and mechanisms of rejection, Chapter 15 p. 439 - 470

Mar. 9 (Wed) – Immunosuppressive drugs and tolerance induction

Mar. 11 (Fri) – Immunological responses towards cancer, Chapter 17 p 507 - 517 Mar. 16 (Wed) – Immunotherapy for cancer, Chapter 17 p. 518 - 527

Mar. 18 (Fri) –Exam II

Mar. 23 (Wed) – Student presentations

Mar. 25 (Fri) – Student presentations

Mar. 30 (Wed) – Student presentations

Apr. 1 (Fri) – Student presentations

Apr. 6 (Wed) – Student presentations

Apr. 8 (Fri) – Student presentations

 

COURSE-LEVEL EDUCATIONAL GOALS:

By the end of this course students should:

  1. Know how the immune system protects against infectious diseases
  2. Understand how vaccines work
  3. Understand why the immune system does not normally mount a response against the body’s own tissues
  4. Know how immune responses that cause allergy and asthma develop
  5. Understand how immune responses that target the body’s own tissues develop
  6. Know how immune responses reject transplanted organs
  7. Know how the immune responses protects against cancer

Grading

  • 2 Midterm Exams (30% each) 60%
  • Participation 10%
  • Presentation and written summary 30%

NOTES:

EXAM POLICIES

Grade disputes and re-grades: If points for an exam have not been properly tabulated please indicate this to the TA so a correction can be made (simply done as a Canvas entry).

If you want a question(s) on an exam re-graded, give the exam to your TA; the TA will then bring the exam to the instructor. The instructor will then, in an unbiased fashion, remark the ENTIRE exam. Please note that this could result in the assignment of a LOWER grade. There is a deadline of 1 week from the viewing of a midterm exam for requesting a re-grade.

Exam attendance is mandatory. If I am made aware of extreme, extenuating circumstances, i.e., near-fatal illness, University sports travel, BEFORE the exam, other arrangements can be made. More details will be provided the first day of class.

 

ACADEMIC INTEGRITY AND STANDARDS OF CONDUCT

Simon Fraser University and MBB faculty want students to be individuals of absolute integrity. The following are examples of inappropriate behaviors punishable by the University and the exact penalties are described in the University calendar and Policies S10.01-S10.04 on the web (http://www.sfu.ca/policies/gazette/student.html).

Plagiarism refers to the presenting of words, ideas, or work of others as one’s own work. Plagiarism also includes using one’s own work completed in a previous class for credit in another class without permission of the instructor or paraphrasing another person’s work without giving credit.

Cheating during exams includes, but is not limited to, unauthorized concealed information to which one can refer during an exam, looking at another student’s exam, opening books when not authorized, obtaining advance copies of exam, and having an exam re-graded after making changes to the answer sheet.

Materials

REQUIRED READING:

The Immune System, 5th Ed., Peter Parham, 2021. Norton . ISBN:978-0-393-53334-7


Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity web site http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating.  Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the University community.  Academic dishonesty, in whatever form, is ultimately destructive of the values of the University. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the University. http://www.sfu.ca/policies/gazette/student/s10-01.html

TEACHING AT SFU IN SPRING 2022

Teaching at SFU in spring 2022 will involve primarily in-person instruction, with safety plans in place.  Some courses will still be offered through remote methods, and if so, this will be clearly identified in the schedule of classes.  You will also know at enrollment whether remote course components will be “live” (synchronous) or at your own pace (asynchronous).

Enrolling in a course acknowledges that you are able to attend in whatever format is required.  You should not enroll in a course that is in-person if you are not able to return to campus, and should be aware that remote study may entail different modes of learning, interaction with your instructor, and ways of getting feedback on your work than may be the case for in-person classes.

Students with hidden or visible disabilities who may need class or exam accommodations, including in the context of remote learning, are advised to register with the SFU Centre for Accessible Learning (caladmin@sfu.ca or 778-782-3112) as early as possible in order to prepare for the spring 2022 term.