Fall 2023 - MBB 328 D100
Introduction to Microbial Pathogenesis (3)
Class Number: 4354
Delivery Method: In Person
Course Times + Location:
Sep 6 – Oct 6, 2023: Tue, Thu, 2:30–4:20 p.m.
Oct 11 – Dec 5, 2023: Tue, Thu, 2:30–4:20 p.m.
Exam Times + Location:
Dec 14, 2023
Thu, 3:30–6:30 p.m.
Prerequisites:MBB 231 with a minimum grade of C.
The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on the specific microbes and their virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. Students with credit for MBB 428 may not take this course for further credit.
We will examine the molecular mechanisms by which microbial pathogens colonize the human body and cause disease. Emphasis will be placed on selected microbes and their structure/morphology, genetics, virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections, including antibiotics, antiviral agents and vaccines, will be discussed in detail. Students with credit for MBB 428 may not take this course for further credit.
Host immune response
Overview of virus structure
Selected viral pathogens:
- Polio virus
- Coronaviruses including SARS-CoV2
- Influenza virus
- Human immunodeficiency virus (HIV)
- Human papilloma virus (HPV)
- Herpes simplex virus (HSV)
Antiviral agents and resistance mechanisms
Selected bacterial pathogens:
- Listeria monocytogenes
- Streptococci, Enterococci, Staphylococcus aureus
- Pseudomonas aeruginosa
- pathogenic E. coli
- Klebsiella pneumoniae
Antibiotics and resistance mechanisms
Selected fungal pathogen & parasite
- Two midterm exams and a cumulative final exam 80%
- Assignments 20%
Wilson, A.B. (2023). Introduction to Microbial Pathogenesis for Simon Fraser University ePDF.
REQUIRED READING NOTES:
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Department Undergraduate Notes:
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