Simon Fraser University
Engaging the World

Course Outlines

Spring 2023 - MBB 427 D100

Immune Responses in Health and Disease (3)

Class Number: 3720

Delivery Method: In Person

Overview

  • Course Times + Location:

    Jan 4 – Apr 11, 2023: Wed, 2:30–4:20 p.m.
    Burnaby

    Jan 4 – Apr 11, 2023: Fri, 2:30–4:20 p.m.
    Burnaby

  • Prerequisites:

    One of MBB 326, HSCI 326, MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor.

Description

CALENDAR DESCRIPTION:

Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Students with credit for HSCI 427 cannot take MBB 427 for credit.

COURSE DETAILS:

Course Description
Many diseases are caused by inadequacy or dysregulation of the immune system.  This course will examine the immunological mechanisms underlying vaccination, primary human immunodeficiencies, HIV/AIDS, asthma and allergy, autoimmunity, and organ transplantation.  Immune responses to cancer and cancer immunotherapy will also be discussed. 

Lecture Topics

  1. Evasion and subversion of host defenses by pathogens
  2. Vaccines
  3. Primary human immunodeficiencies
  4. HIV/AIDS
  5. Allergy and hypersensitivity
  6. Induction and maintenance of tolerance
  7. Autoimmunity
  8. Transplantation
  9. Tumor immunology and immunotherapy

COURSE-LEVEL EDUCATIONAL GOALS:

Understand the physiological, cellular, molecular and genetic bases of a range of immunopathologies. Develop insights into immunosurveillance and how cancer and organ transplantation overcome immune responses. Gain depth in the use of current technologies, including immunotherapies. Improve skills developed in MBB/HSCI 426/726 to review and critique papers in the primary literature, in both oral and written formats.

Grading

  • 2 non-cumulative exams (30% each) 60%
  • Tutorial participation 10%
  • Written summary and presentation 30%

Materials

REQUIRED READING:

Original research articles and review articles

The Immune System, 5th Ed., Peter Parham, 2021.  Norton.
ISBN: 978-0-393-53334-7

REQUIRED READING NOTES:

Your personalized Course Material list, including digital and physical textbooks, are available through the SFU Bookstore website by simply entering your Computing ID at: shop.sfu.ca/course-materials/my-personalized-course-materials.

Department Undergraduate Notes:


  • For help with writing, learning and study strategies please contact the Student Learning Commons at
    http://learningcommons.sfu.ca/
  • Students requiring accommodations as a result of a disability, must contact the Centre for Accessible Learning (778-782-3112 or e-mail:  caladmin@sfu.ca)

Registrar Notes:

ACADEMIC INTEGRITY: YOUR WORK, YOUR SUCCESS

SFU’s Academic Integrity website http://www.sfu.ca/students/academicintegrity.html is filled with information on what is meant by academic dishonesty, where you can find resources to help with your studies and the consequences of cheating. Check out the site for more information and videos that help explain the issues in plain English.

Each student is responsible for his or her conduct as it affects the university community. Academic dishonesty, in whatever form, is ultimately destructive of the values of the university. Furthermore, it is unfair and discouraging to the majority of students who pursue their studies honestly. Scholarly integrity is required of all members of the university. http://www.sfu.ca/policies/gazette/student/s10-01.html