Overview

Description

CALENDAR DESCRIPTION:

An intermediate level course in modern organic chemistry, including both theoretical design of synthetic routes and practical training in the laboratory. The central topics to be discussed include methods to form carbon-carbon bonds, use of organometallic reagents, asymmetric synthesis, pericyclic reactions, the use of enzymes in organic synthesis, and the automation of synthetic organic chemistry. Quantitative.

COURSE DETAILS:

Please note, this course outline was accurate at the time of publication but is subject to change.

Mode of Teaching:

3 lecture hours/week and 1 tutorial/week for 9 weeks; 4 lab hours/week for 12 Weeks

Lecture:  In-person at Burnaby campus (Monday, 2:30-3:20 & Wednesday 2:30-4:20)

Tutorial/Prelab:  In-person at Burnaby campus (Monday, 3:30-4:20)

Laboratory:  In-person at Burnaby campus (Tuesday, 13:30-17:20)

Note:

• For practical reasons, the scheduled second lecture period on Mondays will be used as a prelab/tutorial.  Accordingly, the scheduled tutorial period on Wednesdays will be used as a lecture period.
• There is no lab, tutorial or instructor office hours in the first week of classes.

General Course Description:
This is an intermediate level course in modern organic chemistry. A historical description of the subject will be presented and basic functional group interconversion reactions will be reviewed. The central topics to be discussed include methods to form carbon-carbon bonds, organometallic reagents, asymmetric synthesis, pericyclic reactions, the use of enzymes in organic synthesis, and the automation of synthetic organic chemistry. The design of synthetic routes to prepare organic compounds will be introduced and illustrative examples given. The course includes a laboratory component that is designed to provide practical training in synthetic organic chemistry.

Lecture Topics:
Week 1. Historical perspective, chemical literature and database searches, review of basic functional group interconversions.
Week 2. Carbon-carbon bond forming reactions.
Week 3. Organometallic reagents.
Week 4. Asymmetric synthesis.
Week 5. Pericyclic reactions.
MIDTERM EXAM
Week 6. Enzyme-mediated and automated organic synthesis.
Weeks 7-8. Introduction to the design of synthetic routes (retrosynthetic analysis), protecting groups, linear and convergent synthesis.
Week 9. Course review.

Grading

Materials

MATERIALS + SUPPLIES:

Required Materials:

• Lab coat and safety glasses/goggles.

Personal Protective Equipment (PPE): Lab coats and safety glasses/goggles are mandatory in Chemistry for all in-person laboratory sessions. Additional PPE and precautionary measures may be required during in-person laboratory sessions based on the recommendations of the University and provincial health officials.

RECOMMENDED READING:

REQUIRED READING NOTES: