Biophysics and Soft Matter Seminar

Regulation of ETS transcription factors: auto-inhibition and fuzzy complexes

Wed, 18 Jan 2017 1:30 PM
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Biophysics and Soft Matter Seminar
Regulation of ETS transcription factors: auto-inhibition and fuzzy complexes

Lawrence McIntosh
Department of Chemistry, UBC

Jan. 18 2017 at 1:30pm in P8445.2

Synopsis

Transcription factors, such as those of the ETS family, translate the genetic information of an organism by binding specific promoter/enhancer sequences, recruiting additional transcriptional machinery, and responding to signaling pathways. The aberrant activities of these factors, or their upstream regulators, frequently lead to dysregulated gene expression and oncogenesis. Our overall goal is to elucidate the molecular mechanisms underlying control of ETS factors by DNA-binding autoinhibition, protein partnerships and post-translational modifications. An overarching theme of the following aims also lies with understanding the central role of protein dynamics in biological regulation.