Colloquium

Deciphering The Stochastic Kinetics Of Gene Regulation

Fri, 26 Jan 2018 2:30 PM
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Colloquium
Deciphering The Stochastic Kinetics Of Gene Regulation

Ido Golding
Baylor College of Medicine and the Center for Theoretical Biological Physics, Rice University

Jan 26, 2018 at 2:30pm in WMC3260

Synopsis

Gene activity is the prime mover in the living cell, driving a cell’s function at any given time. I will report on recent advances in our ability to describe the stochastic kinetics of gene regulation, achieved through the combination of single-molecule fluorescence microscopy in individual cells, novel image analysis algorithms, and theoretical modeling. We apply our approach to explore gene regulation in a number of organisms representing a gradation of complexity: E. coli bacteria, fly embryos, and mouse embryonic stem cells.