Simon Fraser UniversityDepartment of Physics GRADUATE STUDENTS INFORMATION
PUBLICATIONS
 

J. Thewalt Publications

  1. Robert J. Cushley, Bruce J. Forrest, Anne Gillis, and Jenifer Tribe, Structures and properties of mixtures of branched chain compounds and lecithin: phytol, [alpha]-tocopherol (vitamin E), and phytanic acid, Canadian Journal of Chemistry, Volume 57, Number 4, 458-465 (1979).

  2. Jenifer Thewalt, Tenkasi S. Viswanathan, and Robert J. Cushley, An electron spin resonance spectral study of the dynamics of spin-labelled fatty acids bound to oxidoreductases, Canadian Journal of Biochemistry and Cell Biology, Volume 61, Numbers 2 & 3, 144-149 (1983).

  3. Jenifer L. Thewalt, Stephen R. Wassall, Heiner Gorrissen and Robert J. Cushley, Deuterium NMR study of the effect of n-alkanol anesthetics on a model membrane system, Biochimica et Biophysica Acta 817, 355-365 (1985).

  4. Jenifer L. Thewalt, Alexander P. Tulloch and Robert J. Cushley, A deuterium NMR study of labelled n-alkanol anesthetics in a model membrane, Chemistry and Physics of Lipids 39, 93-107 (1986).

  5. Stephen R. Wassall, Jenifer L. Thewalt, Linda Wong, Heiner Gorrissen, and Robert J. Cushley, Deuterium NMR study of the interaction of [alpha]-Tocopherol with a phospholipid model membrane, Biochemistry, 25, 319-326 (1986).

  6. Jenifer L. Thewalt and Robert J. Cushley, Phospholipid/cholesterol membranes containing n-alkanols: a 2H-NMR study, Biochimica et Biophysica Acta 905, 329-338 (1987).

  7. Junshi Yue, Jenifer L. Thewalt and Robert J. Cushley, Deuterium nuclear magnetic resonance study of the interaction of branched chain compounds (phytanic acid, phytol) with a phospholipid model membrane, Chemistry and Physics of Lipids, 49, 205-213 (1988).

  8. Book Chapter: M. Bloom, C. Morrison, E. Sternin, and J.L. Thewalt, Spin echoes and the dynamic properties of membranes, 274-316 in "Pulsed Magnetic Resonance: NMR, ESR and Optics" (D.M.S. Bagguley, ed.) Clarendon Press, Oxford 1992.

  9. Jenifer L. Thewalt, Caireen E. Hanert, Frank M. Linseisen, Andrew J. Farrall and Myer Bloom, Lipid-sterol interactions and the physical properties of membranes, Acta Pharm. 42, 9-23 (1992).

  10. Jenifer L. Thewalt and Myer Bloom, Phosphatidylcholine: cholesterol phase diagrams, Biophys. J., Volume 63, 1176-1181 (1992).

  11. Jenifer Thewalt, Neil Kitson, Cyndy Araujo, Alex MacKay, and Myer Bloom, Models of stratum corneum intercellular membranes: the sphingolipid headgroup is a determinant of phase behavior in mixed lipid dispersions, Biochemical and Biophysical Research Communications, Vol. 188, No. 3, 1247-1252 (1992).

  12. Frank M. Linseisen, Jenifer L. Thewalt, Myer Bloom and Thomas M. Bayerl, 2H-NMR and DSC study of SEPC-cholesterol mixtures, Chemistry and Physics of Lipids, 65, 141-149 (1993).

  13. Myer Bloom and Jenifer Thewalt, Spectroscopic determination of lipid dynamics in membranes, Chemistry and Physics of Lipids 73, 27-38 (1994).

  14. Neil Kitson, Jenifer Thewalt, Michel Lafleur, and Myer Bloom, A model membrane approach to the epidermal permeability barrier, Biochemistry, Vol. 33, No. 21, 6707-6715 (1994).

  15. David B. Fenske, Jenifer L. Thewalt, Myer Bloom, and Neil Kitson, Models of stratum corneum intercellular membranes: 2H NMR of macroscopically oriented multilayers, Biophysical Journal, Volume 67, 1562-1573 (1994).

  16. Myer Bloom and Jenifer L. Thewalt, Time and distance scales of membrane domain organization, Molecular Membrane Biology, 12, 9-13 (1995).

  17. Book Chapter: William Abraham, Neil Kitson, Myer Bloom, Jenifer L. Thewalt, Investigation of Membrane Structure and Dynamics by Deuterium NMR: Application to the Stratum Corneum, 163-197 in "Mechanisms of Transdermal Drug Delivery" (Russell O. Potts and Richard H. Guy, eds.). Publisher, Marcel Dekker (1997).

  18. J.A. Bouwstra, J. Thewalt, G.S. Gooris and N. Kitson, A Model Membrane Approach to the Epidermal Permeability Barrier: An X-ray Diffraction Study, Biochemistry, Vol. 36, No. 25, 7717-7725 (1997).

  19. Drobnies, A.E., van der Ende, B., Thewalt, J.L. and Cornell, R.B. (1999) 'CTP:phosphocholine cytidylyltransferase activation by oxidized phosphatidylcholines correlates with a decrease in lipid order: A 2H NMR analysis', Biochemistry 38:15606-14.

  20. Kitson, N. and Thewalt, J.L. (2000) 'Hypothesis: the epidermal permeability barrier is a porous medium', in 'Frontiers of Skin Barrier Research' Acta Dermatologia-Venereologica Supp. 208:11-15. (invited article)

  21. Nielsen, M., Thewalt, J., Miao, L., Ipsen, J.H., Bloom, M., Zuckermann, M.J. and Mouritsen, O.G. (2000) 'Sterol evolution and the Physics of Membranes', Europhys. Lett. 52:368-374.

  22. Hsueh, Y.-W., Giles, R., Kitson, N. and Thewalt, J. (2002) 'The Effect of Ceramide on Phosphatidylcholine Membranes: a Deuterium NMR Study', Biophys. J. 82:3089-3095.

  23. Miao, L., Nielsen, M., Thewalt, J., Ipsen, J.H., Bloom, M., Zuckermann, M.J. and Mouritsen, O.G. (2002) 'From Lanosterol to Cholesterol: Structural Evolution and Differential Effects on Lipid Bilayers', Biophys. J. 82:1429-1444.

Book Chapters:

1. Abraham, W., Kitson, N., Bloom, M. and Thewalt, J. (1997) ‘Investigation of Membrane Structure and Dynamics by Deuterium NMR: Application to the Stratum Corneum’ in Mechanisms of Transdermal Drug Delivery (Eds. R.O. Potts and R.H. Guy), Marcel Dekker, New York, pp. 163-198.

2. Hsueh, Y.-W., Thewalt, J., Kitson, N. and Moore, D. ‘Stratum Corneum Lipid Structure: Insights from NMR and FTIR Spectroscopic Studies’ to be published by Marcel Dekker in ‘Hair, Skin and Nails’, ed. Magnus Lindberg.

Non-refereed contributions
Abstracts (posters/talks):

1. 20th International Conference on Magnetic Resonance in Biological Systems, Toronto, ON, Aug. 25-30, 2002. L.M.R. Singh and J.L. Thewalt ‘NMR Studies of Membrane Binding Peptides in Cubic Lipid Phases’.

2. CSBMCB 45th Annual Meeting and Winternational Symposium, Banff, AL, Mar. 2002. L.M.R. Singh and J.L. Thewalt ‘NMR Structural Studies of Model Transmembrane Peptides Bound to Cubic Lipid Phases’.

3. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA, Feb. 23-27, 2002. J.L. Thewalt, Y.-W. Hsueh, N. Kitson ‘Domain formation in POPC:ceramide model membranes’.

4. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA, Feb. 23-27, 2002. Ya-Wei Hsueh, J. Thewalt, C. Trandum, P. Westh and Martin Zuckermann ‘The phase behavior of dipalmitoylphosphatidylcholine–ergosterol multibilayers’.

5. Canadian Association of Physicists Congress, Victoria, B.C., June 17-20, 2001. Ya-Wei Hsueh, R. Giles, T. Luchko, N. Kitson and J. Thewalt ‘The effect of ceramides on phospholipid bilayers: a deuterium NMR study’.

6. 84th Canadian Society of Chemistry Conference, Montreal, Quebec, May 26-30, 2001; 44th Annual Meeting of the Canadian Society of Biochemistry and Molecular & Cellular Biology, Alliston, Ont., May 31-June 3, 2001. L.M.R. Singh, C. Robertson and J.L. Thewalt ‘Recombinant Expression and Purification of 15N-Labelled Model Transmembrane Peptides for NMR Studies in Cubic Lipid Phases’.

7. 45th Annual Meeting of the Biophysical Society, Boston, USA, Feb. 17-21, 2001. Ya-Wei Hsueh, R.Giles, T. Luchko, N. Kitson and J. Thewalt ‘2H NMR study of ceramide in a phospholipid membrane’.

8. 44th Annual Meeting of the Biophysical Society, New Orleans, USA, Feb. 12-16, 2000. N. Kitson, M. Monck, S. Wang and Jenifer L. Thewalt ‘Why doesn’t skin leak (much)? Water flux across model stratum corneum membranes’.

9. 44th Annual Meeting of the Biophysical Society, New Orleans, USA, Feb. 12-16, 2000. M. Nielsen, J. Thewalt, L. Miao, J.H. Ipsen, M. Bloom, M.J. Zuckermann and O.G. Mouritsen ‘Evolution and the differential effect of cholesterol and lanosterol on the physical properties of membranes’.

10. 44th Annual Meeting of the Biophysical Society, New Orleans, USA, Feb. 12-16, 2000. A.E. Drobnies, J.L. Thewalt, B. van der Ende and R.B. Cornell ‘Membrane disorder by oxidized phosphatidylcholines (PCs) correlates with activation of CTP:Phosphocholine cytidylyltransferase (CT)’.

11. Gordon Research Conference on the Barrier Function of Mammalian Skin, Il Ciocco, Italy, Apr. 18-23, 1999. Jenifer Thewalt, Amy Rowat and Neil Kitson ‘Model stratum corneum membranes: effects of a penetration enhancer’.

12. 43rd Annual Meeting of the Biophysical Society, Baltimore, MD, Feb. 13-17, 1999. R. Giles and J.L. Thewalt ‘Model characterization of the effects of ceramide on the lipid bilayer’.

13. 40th Experimental Nuclear Magnetic Resonance Conference, Orlando, Fl. Feb. 28 - Mar. 5, 1999. Xin Chen, Myer Bloom, Neil Kitson and Jenifer Thewalt ‘A 2H-NMR study of the effect of free fatty acid and ceramide chain length on phase coexistence in model stratum corneum membranes’.

14. 42nd Annual Meeting of the Biophysical Society, Kansas City, MO, USA, Feb. 21-26, 1998. J.L. Thewalt, D. Langlais, X. Chen and N. Kitson ‘News from the Edge of Mammalian Biology: Progress in Understanding the Skin Barrier Membrane’

15. Gordon Research Conference on the Barrier Function of Mammalian Skin, Tilton, NH, Aug. 10-15, 1997. ‘The influence of fatty acid chain length on the phase behaviour of SC model membranes’ Chen, X., Bloom, M., Kitson, N. and Thewalt, J.

16. Gordon Research Conference on the Barrier Function of Mammalian Skin, Tilton, NH, Aug. 10-15, 1997. ‘The effect of ceramide chain length on the phase behaviour of SC model membranes’ Langlais, D., Bloom, M., Neil Kitson, N. and Thewalt, J.

17. Gordon Research Conference on the Barrier Function of Mammalian Skin, Tilton, NH, Aug. 10-15, 1997. ‘Interactions between oleic acid and SC model membranes’ Rowat, A., Kitson, N. and Thewalt, J.

18. Gordon Research Conference on "Lipids and Lipid Mediators" at Kimball Union Academy, New Hampshire, June 22-27, 1997. ‘Activation of CTP:Phosphocholine Cytidylyltransferase by Multilamellar Vesicles containing Oxidized Phospholipids is Correlated with Decrease in Bilayer Order Parameter’, Drobnies, A.E., Venczel, E., Thewalt, J.L., van der Ende, B., Cornell, R.B.

Colloquia and Seminars at Other Universities:

1. Technical University of Denmark, Dept. of Physical Chemistry Mar. 23, 1999 and Umea University, Sweden, Dept. of Physical Chemistry Mar. 19, 1999. ‘The epidermal permeability barrier as porous medium’.

2. Complexity Series, University of British Columbia, Nov. 24, 1998. ‘Molecular Architecture and the Skin Barrier’.

3. Department of Chemistry, Universite de Montreal, Aug. 18, 1997. ‘Model Membranes and the Skin Barrier’.


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