Displayed Output

The NLMIXED Procedure

Displayed Output

This section describes the displayed output from PROC NLMIXED. See the section "ODS Table Names" for details about how this output interfaces with the Output Delivery System.

Specifications

The NLMIXED procedure first displays the "Specifications" table, listing basic information about the nonlinear mixed model that you have specified. It includes the principal variables and estimation methods.

Dimensions

The "Dimensions" table lists counts of important quantities in your nonlinear mixed model, including the number of observations, subjects, parameters, and quadrature points.

Parameters

The "Parameters" table displays the information you provided with the PARMS statement and the value of the negative log likelihood function evaluated at the starting values.

Starting Gradient and Hessian

The START option in the PROC NLMIXED statement displays the gradient of the negative log likelihood function at the starting values of the parameters. If you also specify the HESS option, then the starting Hessian is displayed as well.

Iterations

The iteration history consists of one line of output for each iteration in the optimization process. The iteration history is displayed by default because it is important that you check for possible convergence problems. The default iteration history includes the following variables:

Iter, the iteration number
Calls, the number of function calls
NegLogLike, the value of the objective function
Diff, the difference between adjacent function values
MaxGrad, the maximum of the absolute (projected) gradient components (except NMSIMP)
Slope, the slope g^Ts of the search direction s at the current parameter iterate $\theta_{(k)}$ (QUANEW only)
Rho, the ratio between the achieved and predicted value of Diff (NRRIDG only)
Radius, the radius of the trust region (TRUREG only)
StdDev, the standard deviation of the simplex values (NMSIMP only)
Delta, the vertex length of the simplex (NMSIMP only)
Size, the size of the simplex (NMSIMP only)

For the QUANEW method, the value of Slope should be significantly negative. Otherwise, the line-search algorithm has difficulty reducing the function value sufficiently. If this difficulty is encountered, an asterisk (*) appears after the iteration number. If there is a tilde ${({\scriptsize{\sim}})}$ after the iteration number, the BFGS update is skipped, and very high values of the Lagrange function are produced. A backslash (\ ) after the iteration number indicates that Powell's correction for the BFGS update is used.

For methods using second derivatives, an asterisk (*) after the iteration number means that the computed Hessian approximation was singular and had to be ridged with a positive value.

For the NMSIMP method, only one line is displayed for several internal iterations. This technique skips the output for some iterations because some of the termination tests (StdDev and Size) are rather time consuming compared to the simplex operations, and they are performed only every five simplex operations.

The ITDETAILS option in the PROC NLMIXED statement provides a more detailed iteration history. Besides listing the current values of the parameters and their gradients, the following values are provided in addition to the default output:

Restart, the number of iteration restarts
Active, the number of active constraints
Lambda, the value of the Lagrange multiplier (TRUREG and DBLDOG only)
Ridge, the ridge value (NRRIDG only)
Alpha, the line-search step size (QUANEW only)

An apostrophe (') trailing the number of active constraints indicates that at least one of the active constraints was released from the active set due to a significant Lagrange multiplier.

Fitting Information

The "Fitting Information" table lists the final maximized value of the log likelihood as well as the information criteria of Akaike and Schwarz in two different forms. The smaller-is-better forms are as follows.

$AIC &=& 2f(\hat{\theta}) + 2n \ BIC &=& 2f(\hat{\theta}) + n \log (s)$

where $\hat{\theta}$ is the vector of parameter estimates and s is the number of subjects. The larger-is-better forms for AIC and BIC multiply the preceding values by -0.5.

Parameter Estimates

The "Parameter Estimates" table lists the estimates of the parameter values after successful convergence of the optimization problem or the final values of the parameters under nonconvergence. If the problem did converge, standard errors are computed from the final Hessian matrix. The ratio of the estimate with its standard error produces a t value, with approximate degrees of freedom computed as the number of subjects minus the number of random effects. A p-value and confidence limits based on this t distribution are also provided. Finally, the gradient of the negative log likelihood function is displayed for each parameter, and you should verify that they each are sufficiently small for non-constrained parameters.

Covariance and Correlation Matrices

Following standard maximum likelihood theory (for example, Serfling 1980), the asymptotic variance-covariance matrix of the parameter estimates equals the inverse of the Hessian matrix. You can display this matrix with the COV option in the PROC NLMIXED statement. The corresponding correlation form is available with the CORR option.

Additional Estimates

The "Additional Estimates" table displays the results of all ESTIMATE statements that you specify, with the same columns as the "Parameter Estimates" table. The ECOV and ECORR options in the PROC NLMIXED statement produce tables displaying the approximate covariance and correlation matrices of the additional estimates. They are computed using the delta method (Billingsley 1986). The EDER option in the PROC NLMIXED statement produces a table displaying the derivatives of the additional estimates with respect to the model parameters evaluated at their final estimated values.

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