Dr. Timothy Audas
RNA Biology, Amyloidogenesis, Neurological Diseases
Dr. Audas is interested in how cells respond to changes in their environment. Recently, he showed that a class of biological molecules – noncoding RNA – is essential to many of the stress response pathways used by cells to adapt to changing conditions. In particular, he discovered a noncoding RNA-mediated pathway that causes cellular proteins to clump (i.e., form amyloids) under stress conditions; he suspects that this pathway can go awry and lead to neurological disorders, like Alzheimer’s or Parkinson’s. Could these diseases be activated by cellular stress events? The increasing incidence of neurological diseases motivates Dr. Audas to unravel how this pathway works and identify compounds that may cause or disassemble amyloids.
Read more: an interview with Dr. Audas, his profile on the Department of Molecular Biology & Biochemistry website and his lab website