Nansheng J. Chen

Jack Chen, Associate Professor

Department of Molecular Biology and Biochemistry
Simon Fraser University

Office: SSB8111
Phone: (778)782-4823
Email: chenn(at)sfu.ca

B.Sc., Fudan University, Shanghai
Ph.D., Chinese Academy of Sciences, Qingdao

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Synthetic Rescue

REVIEWS

Protein networks in disease (Ideker et al., Genome Research, 2008)
Predicting synthetic rescues in metabolic networks (Motter et al., Molecular Systems Biology, 2008)
Network From Obesity to the "Diseasome" (Barabasi, New England Journal of Medicine, 2007)
Exploring genetic interactions and networks with yeast (Boone et al., Nature Review Genetics, 2007)
Integrating physical and genetic maps: from genomes to interaction networks (Beyer et al., Nature Review Genetics, 2007)
Genetic interactions in yeast: is robustness going bust? (Kupiec et al., Molecular Systems Biology, 2007)
The human disease network (Goh et al., PNAS, 2007)
Network biology: understanding the cell's functional organization (Barabasi et al., Nature Review Genetics, 2004)
Lethal combinations (Tucker and Fields, Nature Genetics, 2003)

Research Articles

Genotype to Phenotype: A Complex Problem (Dowell et al., Science, 2010)
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation (Lin et al., Genes & Development, 2008)
Networking metabolites and diseases (Braun et al., PNAS, 2008)
Multiple knockout analysis of genetic robustness in the yeast metabolic network (Deutscher et al., Nature Genetics, 2006)
Test of synergistic interactions among deleterious mutations in bacteria (Elena et al., Nature, 1997)

Synthetic lethality

Genome-scale gene/reaction essentiality and synthetic lethality analysis (Suthers et al., Molecular Systems Biology, 2009)
Synthetic lethality: a framework for the development of wiser cancer therapeutics (Kaelin, Genome Medicine, 2009)