In general, I am interested in the structure and function of biological systems at different levels. In terms of basic research, I and other members of my group study molecular and cellular mechanism of physiological regulation, e.g., biological transport and signaling, genetic and epigenetic control. In much of our work, we develop these interests in the context of nutrition and metabolism: endocytic transport of nutrients, nutritional epigenetics, transport-function relations of hormones and other regulatory/metabolic factors.
We also research some of these topics in more of an applied context. Basic work on biological transport and transport proteins is also considered in a pathological or therapeutic perspective: basic studies on the endocytic transport of vitamins A, D, and other nutrients, for example, can contribute to a better understanding of the modulation of such transport in cancer cells, or more generally to the identification of pharmaco-modulators of the transport process. One of the nutrient/hormone transport proteins that we study, transthyretin, is also a factor in some amyloidogenic neurodegenerative diseases; its related cellular toxicity mechanisms are being investigated by our group. Another area of interest is that of dietary phytochemicals and human health, e.g., how they contribute to health and longevity, antioxidant activities, and how they may impact pathological processes involved in cancer, cardiovascular, neurodegenerative and other chronic diseases. More specific studies of these and other topics are given in the publications selection below.
Recent theses supervised & Selected publications:
- Sarah Chen, M.Sc. Thesis: Physiological Mechanisms of Nutrient Transport: Vitamin A and Retinol-Binding Protein
- Kris Beking, M.Sc. Thesis: Flavonoids and Neuroprotection: Biochemical and Population-Based Analyses
- VH Fong, Ph.D. Thesis: Molecular and Cellular Studies of Transthyretin and Related Amyloid Pathogenesis
- Beking K, and Vieira A. (2010) Flavonoid intake and incidence of Alzheimers and related dementias: a population based study involving 23 developed countries. Public Health Nutr. 13:1403-09
- Vieira, A. Epigenetic regulation by retinoids. In Epigenetics in Nutrition. Wiley-Blackwell, Oxford
- Aftab et al, (2010) Comparative antioxidant activities and synergism of resveratrol and oxyresveratrol. Nat. Prod. Res. 24:1726-33
- Yao Y, Vieira A. (2007) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. Neurotox. 28:93-100
- Huang J., and Vieira, A. (2006) Evidence for a specific cell membrane retinol-binding protein transport mechanism in a human keratinocyte line. Int. J. Mol. Med. 17:627-31
- Vieira A. (2006) Atypical mutational properties of human chromosome 21 suggested by genome-scale analyses. Cytogen. Genome Res. 115:30-34
- Kyrylov et al. (2005) Modelling the human hypothalamic-pituitary-adrenal axis. IEEE Trans. Biomed. Engineer. 52:1977-1983.
- Vieira et al. (2003) Internalization of glial cell-derived neurotrophic factor receptor GFRalpha1 in the absence of the Ret tyrosine kinase co-receptor. Cell. Mol. Neurobiol. 23:43-55
- Vieira et al. (1996) Control of EGF Receptor Signaling by Clathrin-mediated Endocytosis. Science 274:2086-2089
- Vieira et al. (1995) Receptor-mediated endocytosis of circulatory transthyretin by the avian oocyte. J. Biol. Chem. 270:2952-2956